摘要
Anew research study evaluated the mechanisms of prostate cancer （PCa）resistance to androgen deprivation therapy （ADT） and progression to castrate-resistant disease. Using a codinical approach, the investigators were able to identify key gen-etic determinants of ADT resistance, gain insight into the molecular pathways that play a key role in this transition and pro-pose a potential management strategy to overcome ADT resistance in select cancers. This represents a step forward towards per-sonalized medicine guided by specific molecular markers of prostate cancer enab-ling more effective therapies targeted towards altered metabolic pathways.
Anew research study evaluated the mechanisms of prostate cancer （PCa）resistance to androgen deprivation therapy （ADT） and progression to castrate-resistant disease. Using a codinical approach, the investigators were able to identify key gen-etic determinants of ADT resistance, gain insight into the molecular pathways that play a key role in this transition and pro-pose a potential management strategy to overcome ADT resistance in select cancers. This represents a step forward towards per-sonalized medicine guided by specific molecular markers of prostate cancer enab-ling more effective therapies targeted towards altered metabolic pathways.
