医院获得性肺炎铜绿假单胞菌感染危险因素与耐药性分析

Analysis of resistance and risk factors of Pseudomonas aeruginosa causing hospital acquired pneumonia

目的探讨医院获得性肺炎铜绿假单胞菌感染患者临床危险因素及耐药性特点。方法检测临床分离出铜绿假单胞菌42例肺部感染患者的药物敏感性,结合临床危险因素进行危险因素和耐药性统计分析。结果本组中老年患者占59.52%;药物敏感试验显示有多重耐药性,对氨苄西林/舒巴坦、头孢曲松的耐药率>97%,对多黏菌素E、阿米卡星的敏感率>90%;年龄、基础疾病、贫血、低蛋白血症、侵入性操作及应用广谱抗生素是铜绿假单胞菌感染主要危险因素。结论 医院获得性肺炎铜绿假单胞菌感染与危险因素有关,合理使用抗生素、严格无菌操作等是控制医院内感染的重要措施。

Objective To analyze the resistance and clinic risk factors of Pseudomonas aeruginosa causing hospital acquired pneumonia. Methods The antimicrobial susceptibility of 42 Pseudomonas aeruginosa strains isolated from nosocomial pneumonia was tested. The risk factors and drug resistance of these strains were analyzed. Results The statistics demonstrated that 59.52% of the patients were the elderly. Drug susceptibility test showed that these strains were resistant to multiple drugs. More than 97% of these strains were resistible to Ampicillin/Subactam and Ceftriaxone Sodium, and more than 90% of these strains were susceptible to Polymyxin E Sulfate and Amikacin. The age, underlying diseases, anemic, lower serum protein, invasive operation and use of broad spectrum antibiotics were the mainly risk factors. Conclusion Pseudomona saeruginosa causing hospital acquired pneumonia is correlated with the risk factors. It is important for hospital infection control to use antibiotics reasonably and carry out strict aseptic operation.