慢性阻塞性肺疾病中瘦素及白介素-6的作用和意义

Roles of leptin and interleukin-6 in chronic obstructive pulmonary disease

目的研究慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者中瘦素(leptin)、白介素-6(IL-6)的表达来分析leptin、IL-6在此种疾病中的作用及意义,研究leptin与IL-6的相关性。方法 COPD患者分为急性加重期(acute exacerbatiors of COPD,AECOPD)组、稳定期组和正常对照组。采集各组病例的血清及痰液,放免法测定leptin及IL-6的水平,分析两者在各组之间的差异及其相关性。结果 AECOPD患者血清leptin和IL-6明显高于正常对照组及稳定期患者,稳定期患者血清二者水平较正常对照组略有升高,差异无统计学意义(P>0.05)。AECOPD患者痰液leptin和IL-6较稳定期患者及正常对照组显著增高,稳定期患者痰液中二者的表达较正常组略有升高,差异无统计学意义(P>0.05)。同时AECOPD患者血清白蛋白(ALB)较稳定期患者及正常对照组明显减低,AECOPD组患者白细胞(WBC)较稳定期患者及正常对照组明显升高,AECOPD组患者肺功值较稳定期患者及正常对照组明显下降。稳定期患者ALB和肺功较正常对照组有所降低,WBC水平略有升高,两组间肺功差异有统计学意义(P<0.05),而ALB及WBC差异无统计学意义(P>0.05)。结论 Leptin与IL-6在COPD的发生、发展过程中起着一定的作用,与COPD的病情严重程度有关。

Objective To study the expression of leptin and interleukin-6 （IL-6） in patients with chronic obstructive pulmonary disease （COPD） and to analyze the role and significance. Methods COPD patients were divided into 2 groups： acute exacerbations of COPD （AECO- PD） and stable COPD. Controls were healthy subjects. Leptin and IL-6 were compared in ser- um and sputum samples. Results In AECOPD patients, leptin and IL-6 in both serum and sputum were significantly higher than those in stable COPD patients and controls, stable COPD patients with serum and sputum levels slightly higher than controls, there was no statistically significant difference. AECOPD patients with serum albumin （ALB） was significantly lower than stable COPD patients and controls, white blood cell （WBC） was significantly increasedthan stable COPD patients and controls. AECOPD patients with pulmonary function values de- creased significantly than stable COPD patients and controls. ALB and lung function values in stable COPD patients decreased compared with controls, WBC levels increased slightly, there was significant difference between the two groups in lung function （P 〈 0. 05）, while ALB and WBC had no significant difference （P 〉 0. 05 ）. Conclusion Leptin and IL-6 play important roles in the occurrence and development of COPD. It is associated with the disease severity of COPD.