低密度脂蛋白相关受体1B在乳腺癌中的表达及意义

Expression of low density lipprotein receptor-related protein 1B in tissues of breast carcinoma and its clinical pathological significance

目的研究低密度脂蛋白相关受体1B基因(LRP1B)在乳腺癌中的表达情况,同时探讨其在乳腺癌发生发展中的作用。方法采用原位杂交方法检测LRP1B在128例乳腺癌组织及128例癌旁正常组织中的表达变化,并与临床病理资料作对照分析。结果 128例乳腺癌组织中有42例LRP1B表达阳性,阳性率为32.8%,128例癌旁正常组织阳性表达率100%,二者比较差异显著(P<0.05);LRP1B在乳腺癌中的表达与肿瘤的WHO分级、TNM分期、淋巴结转移呈负相关(P<0.05);与患者的年龄、肿瘤部位及肿瘤大小无相关性(P>0.05)。结论 LRP1B在乳腺癌中的表达下调或缺失对乳腺癌的预后判断有一定的参考价值。

Objective To investigate the expression of low density lipprotein receptor-related protein 1B （LRP1B） in breast carcinoma and relationship with pathological clinical features, then explore the possible effect in the development of breast carcinoma. Methods In situ hy- bridization was used to detect the expression of LRP1B in 128 normal breast tissues and 128 breast carcinoma specimens. Results Of 128 cases of breast cancer specimens, 42 cases LRP1B expression, the positive rate was 32. 8%. 128 normal colon control group, 128 cases LRP1B expression, the positive rate was 100.0%. The difference between the two groups was significant （P 〈 0.05 ） ; LRP1 B expression in breast cancer had no correlation with ages, tumor locations and tumor sizes （ P 〉 0. 05 ） , had negatively correlation with WHO classification, lymph node metastasis, TNM stage （ P 〈 0.05 ）. Conclusion The reduction or deletion of LRP1B in breast cancer tissue has certain reference value for prognosis of breast cancer.