抑癌基因PTEN在非小细胞肺癌中的表达研究

Expression of PTEN in non-small-cell lung carcinoma

目的探讨抑癌基因PTEN表达与非小细胞肺癌(non-small-cell lung carcinoma,NSCLC)发生和发展的关系。方法应用免疫组织化学法检测45例非小细胞肺癌组织和相应癌旁组织中PTEN的表达。结果 PTEN在非小细胞癌组织和相应癌旁组织中阳性表达率分别为31.1%和66.7%,差异有统计学意义(P=0.001);PTEN表达与非小细胞肺癌分化相关(P=0.000),与患者年龄、性别,肿瘤分型、分期和淋巴结转移无关。结论 PTEN与非小细胞肺癌发生和发展相关。

Objective To investigate whether the expression of phosphatase and tensin homolog deleted on chromosome ten （PTEN） is involved in the initiation and progression of non-small- cell lung carcinoma （NSCLC）. Methods The expression of PTEN was detected in 45 paired NSCLC tumor and adjacent normal tissues by immunohistoehemistry. Results The positive ex- pression rates of PTEN in NSCLC tumor and normal tissues were 31.1% and 66.7% respec- tively, the difference was statistically significant （P = 0. 001 ）. PTEN expressions correlated with the differentiation of the tumor（P = 0. 000）. Conclusion Lack of PTEN expression may be involved in the initiation and progression of NSCLC.