摘要
具有结构多样性的天然产物,因其生理活性独特,在药物方面发挥了重要的作用。近年来,利用天然产物手性骨架、生物相容性以及多修饰位点的特性,进行结构改造和官能团的引入,设计合成的新型天然产物骨架有机功能分子,在阳离子识别、阴离子识别、离子的双响应性识别及分子识别等领域中都发挥了重要作用,成为新型功能分子的研究热点之一。本文介绍近年来以天然产物为骨架设计合成的新型功能分子在分子、离子识别方面的研究现状及其发展前景。
Natural products are usually used as therapeutic drugs and good lead compounds after structural modification and transformation due to their structural diversity and unique biological activities. Because of the characteristics of chiral scaffolds, biocompatibility, and various modification sites, the novel functional molecules based on natural products were designed and applied in molecular and ion recognition. In this review, the development of functional molecules based on natural products in molecular and ion recognition, including cation recognition, anion recognition, dual responsive recognition for ions, molecular recognition, chiral recognition and so on are briefly summarized.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2013年第11期1888-1897,共10页
Progress in Chemistry
基金
国家自然科学基金项目(No.21172130)
国家重点基础研究发展计划(973)项目(No.2012CB821600)资助
关键词
天然产物
手性识别
分子骨架
功能分子
分子离子识别
natural products
chiral recognition
molecular scaffolds
functional molecules
molecular and ion recognition
