脂联素和hs-CRP在冠心病患者病情评估中的临床价值

Value of adiponectin and hs-CRP in the evaluation of coranary heart dis-ease's disease condition

目的研究脂联素和hs-CRP在冠心病患者病情评估中的临床价值。方法根据症状体征将冠心病患者分为稳定型心绞痛组(SAP组)、不稳定型心绞痛组(UAP组)和急性心肌梗死组(AMI组),选择正常健康人为对照(CON组),比较四组研究对象血清脂联素、hs-CRP和Gensini积分的差异,分析脂联素、hs-CRP与Gensini积分相关性。结果 SAP组、UAP组和AMI组冠心病患者脂联素显著低于CON组(P<0.01),hs-CRP和Gensini积分显著高于CON组(P<0.01)。SAP组、UAP组和AMI组脂联素依次降低,hs-CRP和Gensini积分依次升高,差异均具有统计学意义(P<0.01)。SAP组、UAP组和AMI组冠心病患者脂联素与Gensini积分呈负相关(P<0.05),hs-CRP与Gensini积分呈正相关(P<0.05)。结论脂联素和hs-CRP在冠心病患者病情评估中具有重要意义,脂联素水平越低、hs-CRP水平越高,表明冠心病病情越重。

Objective To study the value of adiponectin and hs-CRP in the evaluation of coranary heart disease＇s disease condition. Methods Adiponectin,hs-CRP and Gensini score were detected in patients with coronary heart dis- ease and healthy people. The differences were compared and the correlation between adiponectin, hs-CRP and Gensi- ni score were analyzed. Results The adiponectin in CON group were significantly higher than in SAP group,UAP group and AMI group,while lower in hs-CRP （P〈0.01）. The adiponeetin in SAP group, UAP group and AMI group de- creased successively（P〈0.01 ）,while increased in hs-CRP（P〈0.01 ）.The adiponeetin correlate negatively with Gensini score in SAP group,UAP group and AMI group,while positively in hs-CRP. Conclusion The serous adiponectin and hs-CRP could be severed as in the evaluation of coranary heart disease＇s severity. The lower adiponectin and higher hs-CRP indicate more severe disease conditions.