左氧氟沙星治疗幽门螺杆菌感染的应用研究

Application of levofloxacin in the treatment of Helicobacter pylori infection

目的对幽门螺杆菌感染患者予以左氧氟沙星治疗，以研究其临床效果及治疗的安全性。方法将本院2009年4月1日～2011年4月1日诊断出的幽门螺杆菌感染的患者设为研究对象，随机将其分为治疗组和对照组．治疗组采用奥美拉唑、左氧氟沙星以及阿莫西林进行治疗，对照组使用克拉霉素替换左氧氟沙星治疗。治疗10d．停药4周后行14C呼气检测Hp．对Hp根除率、不良反应发生率进行分析对比。结果通过数据的分析，治疗组根除率高于对照组，治疗组药物不良反应发生率明显低于对照组，数据的比较，差异具有统计学意义（P〈0．05）。结论幽门螺杆菌感染患者使用左氧氟沙星进行治疗，药物不良反应较少，对患者伤害小，治愈率高．应在临床上进一步推广应用。

Objective To be levofloxacin in the treatment of patients with Helicobacter pylori infection, in order to study the clinical effect and safety of treatment. Methods In our hospital from April l, 2009 to April 1, 2011 in the diagnosis of Helicobacter pylori infection patients as the research object,and were randomly divided into treatment group and control group,treatment group with omeprazole,levofloxacin and amoxicillin treatment, control group to re- place levofloxacin therapy with clarithromycin. For 10 days,stop drug 4 weeks after 14C breath detection of Hp,Hp eradication rate, to compare the incidence rate of adverse reaction. Results through the analysis of the data, eradica- tion rate of treatment group was higher than the control group, the treatment group of drug adverse reaction incidence was significantly lower than the control group,compared with the data of the significant differences （P〈 0.05） with statistical significance. Conclusion Patients with levofloxacin for treatment of Helicobacter pylori infection,less ad- verse drug reaction, little injury to patients, the cure rate is high, we should further application in clinical practice.