GnRH-a和孕三烯酮应用于腹腔镜子宫内膜异位症术后的疗效观察

Efficacy of GnRH-a and gestrinone used laparoscopic endometriosis surgery

目的 观察并对比分析GnRH-a和孕三烯酮分别应用于腹腔镜子宫内膜异位症术后的疗效.方法 选取我院2011年11月～2012年1月应用腹腔镜手术治疗的子宫内膜异位症患者100例,根据术后用药情况不同分为Ⅰ组50例予GnRH-a,Ⅱ组50例予孕三烯酮,比较两组患者治疗6个月后的临床症状缓解率、复发率及两组患者治疗前后性激素FSH、LH、E2水平的变化及不良反应.结果 Ⅰ组的完全缓解率、部分缓解率明显高于Ⅱ组（P＜0.05）;但Ⅰ组的复发率分别与Ⅱ组比较,差异均无显著性（P＞0.05）.两组患者治疗后FSH、LH及E2均较治疗前明显降低,且Ⅰ组较Ⅱ组降低幅度更明显（P＜0.05）.Ⅰ组与Ⅱ组出现阴道不规则流血、性欲减退、体重增加、盗汗、潮热、肝功能损害比较,差异无显著性（P＞0.05）.结论 GnRH-a和孕三烯酮分别应用于腹腔镜子宫内膜异位症术后均无明显不良反应,安全性好,但GnRH-a的疗效较孕三烯酮更具优势.

Objective To compare the effect of GnRH-a endometriosis. Methods 100 patients EM were divided into and Gestrinone applied separately laparoscopic surgery for 50 patients in each group, I group was given GnRH-a, Ⅱ group was given Gestrinone,compared the clinical remission rate after 6 months, relapse rate and two groups of pa- tients before and after sex hormones FSH, LH, E2 level changes, adverse reactions. Results The complete remission rate, partial remission rate of I group was significantly higher than that group 11 （P〈0.05） ; but the recurrence rate of had no significant difference between two groups （P〉0.05）. After treatment, FSH, LH and E2 was significantly lower than before treatment, and the Group I lowered more obviously than Group II （P〈0.05）. Group I and II all had irregular vaginal bleeding, loss of libido, weight gain, night sweats, hot flashes, impaired liver function, the difference was not significant（P〉0.05 ）. Conclusion GnRH-a and Gestrinone applied separately laparoscopic en- dometriosis surgery have no significant adverse reactions, have good security, but the efficacy of GnRH-a has more advantages than Gestrinone.