CIK细胞在原发性肝癌三维适形放疗联合TACE治疗中的应用研究

CIK Cells in Primary Liver Cancer Three- dimensional Conformal Radiotherapy Combined with Conventional Therapy,the Application of Research

目的：分析CIK细胞在原发性肝癌三维适形放疗联合TACE治疗中的应用效果。方法：选取我院于2010年1月-2013年4月收治的48例不能实施手术治疗的原发性肝癌的患者，将其均分为2组，其中对照组患者接受三维适形放疗联合TA-CE（肝动脉化疗栓塞）治疗，治疗组患者在此基础上增加使用CIK细胞免疫法对患者实施治疗，对比2组患者的治疗后患者病情发展时间（TTP），并对患者进行为期1年、2年随访，观察患者的生存率。结果：治疗纽患者的所有生存指标其中包括1、3年生存率以及众位生存期显著优于对照组，对比有统计学意义（P〈0．05），所有患者并发症中最为常见的病症为肝功能病症。所有患者中19例（39．9％）患者出现肝功能损伤，均对患者进行保肝等对症治疗。其中治疗组患者常见的不良反应为轻度消化道反应或发热。结论：在三维适形放疗联合TACE治疗原发性肝癌的基础上，增加使用CIK免疫法对患者实施治疗，可有效改善患者的肝脏功能．提高患者机体免疫力．有利于提高患者生命质量．值得在临床医学中应用发展．

Objective： to analysis of CIK cells in primary liver cancer in 3 d conformal radiotherapy combined with conventional appli- cation effect. Methods：our hospital from January 2010 to April 2013 were 48 cases can＇t implement of surgical treatment of primary liver cancer patients, which were divided into two groups, the control group patients received 3 d conformal radiotherapy combined with conven- tional （hepatic artery embolism chemotherapy） treatment, the treatment group patients on the basis of the increased use of CIK cells im- mune method for patients with treatment, compared two groups of patients after the treatment of patients with disease progression （ TIP）, and the period of 1 year, 2 years of follow - up in patients, observe patient surial rates. Results： the treatment group patients were all sur- vival index including 1, 3 year survival rate and the survival was significantly better than control group, compared with statistical signifi- cance （ P 〈 0.05 ）, all the most common complication in patients with symptoms of liver disease. All of the patients in 19 cases （ 39. 9% ） patients with liver function injury, symptomatic treatment on patients with liver, etc. The common adverse reactions in treatment group patients or fever for mild digestive tract reaction. Conclusion：Three dimensional conformal radiotherapy combined with conventional therapy on the basis of primary liver cancer, increasing the use of CIK immune method of treatment for patients can improve the liver function in patients with effective, improve immunity of patients, improve patient quality of life, is worth in clinical medicine application development.