尼卡地平与硝酸甘油在合并高血压颅内动脉瘤手术中降压作用的比较

Comparison on antihypertensive effect between nicardipine and nitroglycerin in the treatment of intracranial aneurysm surgery combined with hypertension

目的观察尼卡地平在合并高血压患者颅内动脉瘤夹闭手术中控制性降压的作用及安全性,并与硝酸甘油对比。方法 36例合并高血压确诊颅内动脉瘤择期手术的患者随机分为尼卡地平组18例(Ⅰ组)和硝酸甘油组18例(Ⅱ组),手术开始需要降压时分别静脉泵入尼卡地平与硝酸甘油,连续监测两组降压期间血流动力学变化。结果两组均可达到较理想的降压效果,但尼卡地平对CVP、HR影响小于硝酸甘油(P<0.05),对颅内压影响硝酸甘油组较尼卡地平组明显(P<0.05),对尿量影响无差异。结论尼卡地平用于合并高血压的颅内动脉瘤手术中降压作用迅速平稳,与常规降压药物相比具有一定的优越性。

Objective To observe the antihypertensive effect and security of nicardipine in the treatment of intracranial aneurysm combined with hypertension, and compare with nitroglycerin. Methods Thirty-six operation patients with in- tracranial aneurysm and hypertension were randomly divided into nicardipine group （group I , 18 cases） and nitro- glycerin group （group II, 18 eases）, when the surgery started and depressurization was needed, intravenous pumped nicardipine and nitroglycerin, and continuously monitored the hemodynamic change. Results Both of the two groups achieved the ideal antihypertensive effect, but nieardipine had less impact on CVP and HR than nitroglycerin （P 〈 0.05）; nitroglycerin had significant impact on intracranial pressure than nicardipine （P 〈 0.05）; there was no significant difference in urine volume between the two groups. Conclusion The antihypertensive eftect of nieardipine is rapid, smooth and steady, and it has certain advantages than conventional antihypertensive drugs.