奥扎格雷钠短程治疗脑梗死的疗效观察

Observation of efficacy of sodium ozagrel in treatment of acute cerebral infarction in the short-term

目的观察奥扎格雷钠短程治疗急性脑梗死的临床疗效。方法选择2012年1月～2013年6月在我院治疗的48例急性脑梗死的患者随机分为两组,两组均予常规脑梗死治疗,治疗组加用奥扎格雷钠80 mg溶于250 mL的生理盐水中进行静脉滴注,2次/d,连用5 d;两组患者于治疗前、治疗后依据中国脑卒中患者临床神经功能缺损程度评分标准(CSS)评定神经功能缺损程度,并记录出血不良事件情况。结果治疗组疗效显著优于对照组,两组疗效差异有统计学意义(P=0.047<0.05);两组出血不良事件发生率无显著差异。结论运用奥扎格雷钠5 d短程治疗急性脑梗死安全有效。

Objective To observe the efficacy of sodium ozagrel in treatment of acute cerebral infarction in the short- term. Methods Forty-eight patients with acute cerebral infarction were randomly divided into two groups ：the treat- ment group（n=24） and the control group（n=24）.Both groups had 14 days for a course of foundation treatment, and the patients in the treatment group received intravenous infusion of sodium ozagrel 80 mg twice a day,for 5 days.The degrees of neurological deficit were assessed according to the Chinese scale of clinical neurological deficit of stroke pa- tients （China stroke scale, CSS） before treatment,and after treatment.Bleeding events were recorded. Results The rate of improvement in the treatment group was better than that in the control group.The difference between the two groups was statistically significant （P=0.047〈0.05）.There was no significantly difference between the two groups in bleeding events. Conclusion Sodium ozagrel has good effect and is reliably safe in the treatment of acute cerebral infarction.