咖啡酸对尿毒症出血患者血小板参数及血小板聚集功能的影响

Effect of caffeic acid on parameters and aggregation of the platelet in patients with uremic bleeding

目的探讨咖啡酸片对尿毒症出血患者血小板参数及血小板聚集功能的影响。方法将慢性肾功能衰竭(尿毒症)引起血小板减少(血小板计数<100×109/L)的患者随机分为观察组和对照组各12例,观察组患者口服咖啡酸片,0.2 g/次,3次/d,不予常规止血药;对照组患者仅给予常规止血药治疗,如维生素K、止血凝酶等,疗程4周。所有患者均在治疗前及治疗过程中每周进行1次血小板参数及血小板功能检测,观察治疗前后血小板参数及血小板功能的变化。结果治疗4周后,观察组患者血小板聚集率、血小板计数(PLT)、平均血小板体积(MPV)及血小板分布宽度(PDW)均较治疗前明显提高(P<0.01),也明显高于对照组(P<0.01)。结论咖啡酸片可改善尿毒症患者血小板参数,可提高其血小板的聚集功能,对尿毒症出血患者有很好的疗效。

Objective To investigate the effect of coffee acid on parameters and aggregation of platelet in patients with uremic bleeding. Methods 24 cases with thrombocytopenia （ platelet count 〈 100×10^9/L） due do chronic renal failure （uremia） were randomly and equally divided into observation group and control group. Coffee acid （0.2 g） was used orally in the observation group,3 times a day, while regular hemostatics, including vitamin k and thrombin, were employed in the control group. All the treatments last for four weeks. The parameters and aggregation of the platelet were tested before the treatment and every week after the treatment started. Results After four-week treatments,the platelet aggregation rate,platelet count （PLT） ,mean platelet volume （MPV） and platelet distribution width （PDW） in the observation group were significantly higher than those before the treatment （ P 〈 0.05 ） and those in the control group （ P 〈 0.01 ）. Conclusion Caffeic acid can improve the platelet aggregation in uremic patients with thrombocytopenia, having a good curative effect on uremic bleeding.