辛伐他汀对急性脑梗死患者血清CRP及IL-6水平的影响

Effect of simvastatin on serum CRP and IL-6 in patients with acute cerebral infarction

目的探讨辛伐他汀对急性脑梗死患者血清C-反应蛋白(CRP)及白细胞介素-6(IL-6)水平的影响。方法将70例急性脑梗死患者应用随机数字表法随机分为观察组和对照组各35例。两组患者均予肠溶阿司匹林口服,皮下注射低分子肝素钙,静脉注射奥扎格雷钠、胞二磷胆碱、6%羟乙基淀粉等常规对症治疗。观察组在此基础上加用辛伐他汀10 mg,1次/d,晚睡前口服,连用14 d。比较两组患者的临床疗效以及治疗前后CRP、IL-6水平的变化。结果观察组患者治疗总有效率(91.4%)明显高于对照组(71.4%),差异有统计学意义(P<0.05)。治疗后两组患者CRP、IL-6水平均较治疗前明显降低(P均<0.05);与对照组比较观察组降幅更显著(P<0.05)。结论合用辛伐他汀治疗急性脑梗死可以提高临床疗效,辛伐他汀可能对CRP、IL-6的生成具有抑制作用。

Objective To investigate the effect of simvastatin on serum CRP and IL-6 in patients with acute cerebral infarction. Methods 70 patients with acute cerebral infarction were randomly divided into the observation group and the control group with 35 cases in each. Conventional treatments, including enteric coated aspirin （os）, low molecular weight heparin calcium （ih）, iOzagrel （ iv）, citicoline （iv） and 6% hydroxyethyl starch （iv）, were used in both groups. Additionally, 10 mg simvastatin was orally used before sleeping every night in the observation group, 14 days as a course. Clinical effects between two groups as well as CRP and IL-6 before and after treatment were compared. Results The total effective rate in the observation group（91.4% ） was higher than that in the control group（71.4% ） ,which has a significant difference （P 〈 0.05）. Serum CRP and IL-6 levels decreased in both groups after the treatment （ both P 〈 0.05）, while the observational group declined more （ P 〈 0.05 ）. Conclusion The combination of simvastatin with other drugs in the treatment of acute cerebral infarction can improve the clinical efficacy, for simvastatin may inhibit the generation of CRP and IL-6.