腺苷钴胺治疗肝炎肝硬化贫血84例疗效分析

Effects analysis of adenosylcobalamin treatment on 84 patients with hepatitis cirrhosis and anemia

目的探讨腺苷钴胺在肝炎后肝硬化合并贫血患者治疗中的意义。方法回顾性分析2007年1月至2012年12月首都医科大学附属北京地坛医院外科所收治的肝炎后肝硬化合并贫血患者共84例,给予腺苷钴胺1.5 mg/次,1次/d,肌肉注射,治疗2周。观察患者治疗前后血红蛋白定量、红细胞计数、网织红细胞等指标的变化情况。结果与治疗前比较,治疗后患者体内血红蛋白、红细胞计数、网织红细胞水平均显著升高,差异均具有统计学意义(P均<0.01)。结论腺苷钴胺治疗肝炎肝硬化合并贫血的患者,可显著提高其体内血红蛋白含量、提高红细胞数量,从而改善其贫血状态。

Objective To analyze the therapeutic importance of adenosylcobalamin on 84 patients with hepatitis cirrhosis and anemia. Methods Data of 84 cases with viral hepatitis cirrhosis and anemia in department of hepatobiliary surgery of Beijing Ditan hospital, Capital Medical University from January 2007 to December 2012 were analyzed by descriptive methods. The patients were treated with adenosylcobalamin （1.5 mg intramuscular injection once a day） for two weeks. The level of hemoglobin quantitative, red blood cell count, reticulocyte count and other related informations before and after treatment were compared, respectively. Results Compared with that before treatment, the hemoglobin and red blood cell count, reticulocyte value of patients were significantly higher after treatment （all P 〈 0.01）. Conclusions Adenosylcobalamin could significantly improve the hemoglobin content and the red blood cell count in patients with viral hepatitis cirrhosis and anemia.