单纯HIV感染AIDS患者治疗前后实验室指标检测结果分析

Analysis on laboratory test results of AIDS patients with simple HIV infection before and after treatment

目的了解单纯HIV感染艾滋病(AIDS)患者治疗前后实验室指标检测结果的变化情况。方法选取2008年12月至2012年3月于本院住院治疗的单纯HIV感染AIDS患者共171例,按照临床检验项目要求抽取患者静脉血分别进行病毒载量、淋巴细胞亚群计数、血清γ-GT活性及乳酸(LACT)浓度;将患者分为病毒载量高值组(139例)和病毒载量低值组(32例)两组,比较分析患者治疗前后各项指标的变化情况。结果单纯HIV感染者治疗前与治疗后3个月比较,血清LACT浓度降低,差异具有统计学意义(P<0.05);治疗前与治疗后6个月比较,CD3、CD4和CD8细胞计数升高,血清LACT浓度降低,差异均具有统计学意义;治疗后3个月和6个月比较,CD3和CD细胞4计数升高,差异均具有统计学意义(P<0.05)。结论对单纯HIV感染AIDS患者治疗前后进行常规实验室指标检测,并动态分析其变化情况,可有效地指导临床治疗,提高患者的生存质量。

Objective To investigate the changes of the laboratory test results of AIDS patients with simple HIV infection before and after treatment. Methods Total of 171 acquired immune deifciency （AIDS） patients with simple HIV infection were selected in December 2008 to March 2012 in our hospital. HIV viral load, lymphocyte subsets count, serum reported γ-glutamyltransferase （γ-GT） activity and lactobionate （LACT） concentration in venous blood were detected according to the clinical test project requirements. The 171 cases divided into viral load high value group （139 cases） and low viral load group （32 cases）. Comparative analysis of the indicators before and after treatment changes. Results Before treatment compared with after treatment for 3 months comparison, among patients with simple HIV infection, the level of serum LACT concentration was signiifcantly reduced （P〈0.05）. Before treatment compared with after treatment for 6 months, the levels of CD3, CD4 and CD8 counts signiifcantly increased, serum LACT concentration signiifcantly decreased （P〈0.05）. Compared treatment for 3 months with 6 months, the CD3 and CD4 counts significantly increased for simple. Conclusions The routine laboratory tests for AIDS patients with simple HIV infection before and after treatment, and the dynamic analysis of the change of circumstance could effectively guide the clinical treatment, improve the quality of life of patients.