慢性苯中毒者血清中叶酸和维生素B_(12)水平的研究

Study on serum levels of folic acid and vitamin B_(12) in patients of chronic benzene poisoning

目的了解慢性苯中毒者血清中叶酸和维生素B12水平,为慢性苯中毒的防治提供依据。方法采用化学发光分析仪和全自动血细胞分析仪分别对实验组13名慢性苯中毒患者和对照组35名正常对照者血清叶酸和维生素B12含量以及血细胞参数进行测定。结果实验组血清叶酸的水平(11.9±5.6)nmol/L明显低于对照组(24.2±8.3)nmol/L(P<0.05),试验组血清维生素B12的水平(154.9±57.2)pmol/L明显低于对照组(372.2±110.1)pmol/L(P<0.05),试验组白细胞(3.5±0.4)×109/L明显低于对照组(7.9±1.9)×109/L(P<0.05),试验组血小板(169.5±71.8)×109/L明显低于对照组(228.4±58.4)×109/L(P<0.05),试验组红细胞(3.8±0.9)×1012/L明显低于对照组(5.1±0.8)×1012/L(P<0.05),试验组血红蛋白(108.5±29.1)g/L明显低于对照组(141.5±16.1)g/L(P<0.05),试验组红细胞压积(33.0±8.0)%明显低于对照组(45.0±4.0)%(P<0.05),试验组红细胞分布宽度(46.3±7.7)fl明显高于对照组(38.8±4.8)fl(P<0.05)。结论慢性苯中毒者血清中叶酸和维生素B12水平偏低,在慢性苯中毒的防治过程中应加强该类物质的补充。

Objective To provide the criteria for prevention and treatment of chronic benzene poisoning through analyzing serum levels of folic acid and vitamin B12 in patients of chronic benzene poisoning. Methods Serum levels of folic acid and vitamin B12 and various blood cell parameters of 13 patients of chronic benzene poisoning and 35 normal controls were detected by chemiluminescence analyzer and automatic blood cell analyzer. Results Serum levels of folic acid and vitamin B12 of experimental group were respectively（11.9 ±5.6）nmol/L and （154.9±57.2） pmol/L, which were obviously lower than those（24.2±8.3） nmol/L and （372.2±110.1） pmol/L of the control group, （P〈0.05）. White blood cell count, red blood cell count, platelet count, hemoglobin concentration and hematocrit of the experimental group were respectively （3.5 ± 0. 4）×10^9/L, （3.8±0.9）×10^12/L, （169.5±71.8）×10^9/L, （108.5±29.1） g/L and （33.0±8.0%）, which were obviously lower than those（7.9 ± 1.9） × 10^9/L, （5.1±0. 8） × 10^12 , （228.4±58.4） ×10^9/L, （141.5±16.1） g/L and （45.0±4. 0）% respectively） of the control group, （P〈0.05）. The width of red blood cell distribution in the experimental group was （46.3±7.7）fl, which was higher than that（38.8 ±4.8） fl of the control group, （P〈0. 05）. Conclusions Folic acid and vitamin B12 should be supplied according to serum levels of folic acid and vitamin B12 in patients of chronic benzene poisoning during the process of its treatment.