新疆维吾尔族患者HPV感染型别临床分析

Study on the Distribution of HPV in 318Gynecological Uyghur Patients in Xinjiang

目的分析新疆维吾尔族妇女子宫颈HPV感染类型及其分布的规律。方法采用导流杂交基因分型技术对318名妇科维吾尔族就诊患者进行HPV基因分型检测。结果 HPV-DNA检测阳性者占21.70%（69/318）。低危型感染12例（20.69%）,以HPV 6和HPV 1l为主;高危型感染46例（79.31%）,以HPV 16、HPV58和HPV68感染为主。多重感染11例,感染率为3.46%。从年龄分布来看,≤25岁的患者占31.48%,HPV感染率最高,其次为50~55岁年龄段的患者占25.71%。结论 HPV分布存在地域和种族差异,加强对新疆各年龄人群,多种型别HPV的筛查,有助于预防宫颈癌的发生及了解HPV感染的转归,并为新疆地区宫颈癌干预提供理论基础。

Objective To study the distribution of human papilloma virus（HPV）subtypes in Uyghur people from gynecological patients in Xinjiang. Methods 21 subtypes of HPV from 318 cases of gynecological patients ＂s cervix swabs were detected using flow-through hybridization and gene chip technology. Results The positive rate of HPV among the 318 women cases was 21. 70%, 12 patients（28.7%）had low-risk subtype infection. The ranking of fre- quencies on the HPV major low-risk subtypes in patients were： HPV6 and 11. 46 patients（79.31%）had high-risk subtype infection. The ranking of frequencies on the HPV major high-risk subtypes in patients were： HPV16 , HPV58 and 68.11 patients （3. 46%） had multiple-subtype infection. Women aged ≤ 25 years old accounted for 31.48% ,followed by 50 to 55 years old. Conclusions Distribution of HPV subtypes have difference of region and race. Detection of HPV subtypes will help to predict the outcome of infection and provide theory bases for HPV in- tervention and cervical cancer prevention in Xinjiang Uyghur women.