IL-25在支气管哮喘患者气道炎症中的表达及临床意义

Expression and significance of interleukin-25 level in airway inflammation of asthmatics

选取2011年5月至2012年4月就诊于山东省千佛山医院的哮喘患者59例为哮喘组,同期同年龄组健康查体正常者47例作为正常对照组.与正常对照组相比,哮喘组患者血清IgE、IL-4、IL-25、嗜酸性粒细胞计数及诱导痰IL-25水平均显著增高,IFN-γ显著降低；而激素治疗后血清嗜酸性粒细胞计数、IL-4、IL-25及诱导痰IL-25的水平均显著降低,IFN-γ水平显著增高,IgE水平无明显变化；相关性分析显示血清IL-25与嗜酸性粒细胞计数、IL-4呈显著正相关,与IFN-γ呈显著负相关,与IgE无显著相关性.

A total of 59 untreated asthmatics and 47 healthy control subjects were recruited from Qianfoshan Hospital of Shandong Province from May 2011 to April 2012.Compared with healthy control subjects,the levels of IL-25 in induced sputum and eosinophils,IgE,interleukin-4 （IL-4） and interleukin25 （IL-25） in serum samples of asthmatics were significantly higher while the level of interferon-gamma （IFN-γ） were much lower.However,after inhaled glucocorticoid treatment,the levels of eosinophils,IL-4 and IL-25 decreased and IFN-γ significantly increased,while the level of IgE showed no significant changes.It was also found the expression of IL-25 was markedly positively correlated with the levels of eosinophils and IL-4 in serum and markedly negatively correlated with the levels of IFN-γ and had no relatio.