鲍曼不动杆菌的耐药与多粘菌素临床应用探讨

Colistin susceptibility in Acinetobacter baumannii and clinical application

目的 了解西安市某三甲医院2年来鲍曼不动杆菌的药敏变迁情况,探讨多粘菌素治疗鲍曼不动杆菌的临床应用效果.方法 回顾分析2010年1月～2011年12月西安市某三甲医院细菌室的分离菌株,统计鲍曼不动杆菌的检出率和体外药敏效果.结果 2010年共分离细菌4552株,2011年7269株;鲍曼不动杆菌检出率分别为583株（12.8％）和934株（12.8％）,为分离菌株第二位.多粘菌素B对鲍曼不动杆菌保持高体外活性,2010和2011年敏感率分别为92％和91％.结论 鲍曼不动杆菌临床检出率很高,药敏试验证实对多粘菌素B保持很高体外活性,多粘菌素是临床治疗鲍曼不动杆菌的选择之一.

Objective Acinetobacter baumannii is common strain in nosocomial infection.Treatment of acinetobacter baumannii infection becomes more and more difficulty because of increasing resistance.We investigate antibiotic susceptibility of acinetobacter baumannii in a xi＇an Three level of first-class hospital in 2 latest years and discuss colistin application in clinical treatment according to this survey and literature at home and abroad.Methods We retrospectively investigated insolated bacteria strains collected by bacteriology room of a xi＇an Three level of first-class hospital from January 2010 to December 2011.We statistically got lab detection rate and antibiotic susceptibility in vitro in acinetobacter baumannii.Results Isolated results were 4552 strains in 2010 and 7269 strains in 2011.The detection rate of acinetobacter baumannii were 12,8％（583 strains in 2011） and 12.8（934 strains in 2011）,which separately ranked the second place out of 5 common isolated strains.Colistin B agaist acinetobacter baumannii keep high activity in vitro.Colistin B susceptibility were 92％ / 91％ in 2010/2011.Conclusion There is very high clinical detection rate in acinetobacter baumannii.Colistin B keeps high activity against acinetobacter baumannii in vitro,colistin is selection of acinetobacter baumannii clinical treatment.