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Slit3/Robo4信号通道对血管新生作用的研究进展 被引量：1

Progress of Slit3/Robo4 signal pathway in angiogenesis
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摘要 Slit蛋白是一种在进化上高度保守的分泌型糖蛋白,其通过与跨膜蛋白受体Robo结合调节神经元前体细胞定向迁移、神经轴突的定向生长和促进轴突发芽。Slit/Robo信号通道还对肿瘤转移、血管生成、心脏形态发生等多种生命活动具有调节作用。Robo4特异性表达于血管内皮细胞,这意味着Robo4在血管新生中起着重要作用。但近来发现Slit3是新的血管新生活性因子,可与其配体Robo4结合促进血管内皮细胞的增殖迁移,本文就Slit3/Robo4信号通道对血管新生的作用进行综述。 Slit protein is an evolutionarily highly conserved secreted glycoprotein and combines with the transmembrahe receptor Robo protein to guide axon pathfinding,to promote axon branching and to control neuronal migration.Slit/Robo signal has a regulatory role in tumor metastasis,angiogenesis,cardiac morphogenesis and other life activities.Robo4 express specifically in vascular endothelial cells and may mean plays an important role in angiogenesis,Repulsive aron guidance molecule Slit3 is a novel angiogenic factor in recent study and combine with its ligand Robo4 to promote the proliferation and migration of vascular endothelial cells.The purpose of this article is to summarize the influence of Slit3/Robo4 signal pathway in angiogenesis.
作者 刘小艳 王浩宇 刘涛
机构地区 南充市中心医院心内科 川北医学院第二临床医学院 川北医学院组织工程与干细胞研究所
出处 《西部医学》 2013年第11期1748-1750,1753,共4页 Medical Journal of West China
基金 南充市应用技术研究与开展项目(12A0040)
关键词 Slit3 Robo4 血管内皮细胞 血管新生 Slit3 Robo4 Vascular endothelial cells Angiogenesis
分类号 R331.32 [医药卫生—人体生理学]
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参考文献31

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共引文献7

同被引文献33

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西部医学
2013年 第11期

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