骨肉瘤中CD147、MMP-2的表达和意义

EXPRESSION AND SIGNIFICANCE OF CD 147 AND MMP-2 IN OSTEOSARCOMA

目的:探讨骨肉瘤组织CD147、MMP-2蛋白的表达及意义。方法:应用免疫组织化学染色SP法检测37例骨肉瘤及10例骨软骨瘤CD147和MMP-2的表达。结果:骨肉瘤中CD147、MMP-2的阳性表达率均明显高于骨软骨瘤;骨肉瘤中CD147、MMP-2的阳性表达与Enneking分期和肺转移有关,且二者的表达呈正相关(P<0.01)。结论:CD147和MMP-2在骨肉瘤的浸润和转移方面起重要作用,联合检测CD147和MMP-2有望成为判断骨肉瘤预后的新指标。

Objective：To investigate the expression and significance of CD147 and MMP-2 in osteosarcoma. Methods： SP immunohistochemical staining was used to detect the expression of CD147 and MMP-2 in 30 cases osteosarcoma and l0 cases osteochondroma. Results：The positive rate of CD 147 and MMP-2 in osteosarcoma were obviously higher than that in osteochondroma. In osteosarcoma, the positive expression of CD 147 and MMP-2 had relations with Enneking stage and pulmonary metastasis; moreover, in osteosarcorna, expression of CD 147 was positively related with MMP-2. Conclusions： CD 147 and MMP-2 play important role in infiltration and metastasis of osteosarcoma. Joint detection of CD 147 and MMP-2 is expected to become a new index for judging the prognosis of osteosarcoma.