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SHIP在口腔鳞癌中表达研究 被引量：1

Expression of SHIP in oral squamous cell carcinoma.
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摘要 目的探讨含SH2结构域的肌醇磷酸酶(SHIP)在口腔鳞癌中的表达。方法选择中国医科大学附属口腔医院口腔颌面外科2008—2011年间收治的36例口腔鳞癌患者,术后应用免疫组化方法对其癌旁正常组织、原发灶及转移淋巴结中SHIP、基质金属蛋白酶(MMP)-2及MMP-9的表达情况进行检测。结果癌旁正常组织中SHIP呈中高强度阳性表达,明显高于原发灶及转移淋巴结(P<0.05);而原发灶及转移淋巴结中MMP-2和MMP-9表达强度显著高于癌旁正常组织(P<0.01)。结论 SHIP基因可能通过负反馈作用来调节肿瘤的侵袭和转移。 Objective To study the expression of SHIP gene in oral squamous cell carcinoma（OSCC）. Methods Adja-cent tissues,primary tumors and metastatic lymph nodes in 36 patients of OSCC from 2008 to 2011 at Department of Oral and Maxillofacial Surgery,School of Stomatology of China Medical University,were collected. The levels of SHIP, MMP-2 and MMP-9 expressions were examined by immunohistochemistry. Results The levels of SHIP in adjacent tis-sues were higher than in others（P〈0.05）. The levels of MMP-2 and MMP-9 expressions in primary tumors and meta-static lymph nodes were higher than in adjacent tissues（P〈0.01）. Conclusion SHIP gene has a negative effect on in-vasion and metastasis in OSCC.
作者 黄绍辉 刘洁 刘法昱 孙长伏
机构地区 中国医科大学附属口腔医院口腔颌面外科 中国医科大学实验技术中心
出处 《中国实用口腔科杂志》 CAS 2013年第10期596-599,共4页 Chinese Journal of Practical Stomatology
基金 辽宁省教育厅科研基金(2008772) 辽宁省自然科学基金(20102286)
关键词 口腔鳞癌 SHIP MMP-2 MMP-9 oral squamous cell carcinoma（OSCC） SHIP MMP-2 MMP-9
分类号 R78 [医药卫生—口腔医学]
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参考文献8

  • 1Osaki M, Oshimura M, Ito H. PI3K-Akt pathway: its functions and alterations in human cancer [ J ]. 2004,9 (6) : 667-676.
  • 2Kim SH, Juhnn YS, Kang S, et al. Human papillomavirus 16 E5 up-regulates the expression of vascular endothelial growth factor through the activation of epidermal growth factor receptor, MEK/ ERK1,2 and PI3K/Akt [J]. Cell Mol Life Sci, 2006,63 (7-8) : 930-938.
  • 3Levine DA, Bogomolniy F, Yee C J, et al. Frequent mutation of the PIK3CA gene in ovarian and breast cancers [J]. Clin CancerRes, 2005,11 (8) : 2875-2878.
  • 4Oda K, Stokoe D, Taketani Y, et al. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcino- ma [J]. Cancer Res,2005,65(23) : 10669-10673.
  • 5Ware MD, Rosten P, Damen JE, et al. Cloning and characteriza- tion of human SHIP, the 145-kD inositol 5-phosphatase that as- sociates with SHC after cytokine stimulation [J] Blood, 1996,88 (8) : 2833-2840.
  • 6Giri D, Ittmann M. Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically local- ized prostate carcinoma [J]. Hum Pathol, 1999,30(4) :419-424.
  • 7张天彪,许丹,关一夫.RECK和MMP-2在口腔鳞癌中的表达及其与侵袭转移关系研究[J].中国实用口腔科杂志,2010,3(5):292-294. 被引量：7
  • 8Xing W, Hamaguchi M. Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells [J]. J Genet Genomics, 2007, 34 (4) :285-293.

二级参考文献10

  • 1Clark JC,Thomas DM.Choong PF,et al.RECK-a newly diseovered inhibitor of metastasis with prognostic significance in multiple forms of cancer[J].Cancer Metastasis Rev,2007,26(3-4):675-83.
  • 2Staun-Ram E,Goldman S,Shalev E.Ets-2 and p53 mediate cAMP-induced MMP-2 expression,activity and trophoblast invasion[J].Reprod Biol Endocrinol,2009.7(1):135.
  • 3Moh MC,Shen S.The roles of cell adhesion molecules in tumor suppression and cell migration:a New paradox[J].Cell Adh Migr,2009,3(4):334-336.
  • 4Van-de-wiele C,Oltenfreiter R.Imaging probes targeting matrix metalloproteinases[J].Cancer Biother & Radiopharmac,2006,21(5):409-417.
  • 5Boden G,Song WW.Effects of insulin and free fatty acids on matrix metalloproteinases[J].Curr Diab Rep,2008,8(3):239-242.
  • 6Welm B,Mort J,Werb Z.Developmental biology:vasculogenesis is a wreck without RECK[J].Curt Biol,2002,12(6):R209-211.
  • 7Noda M,Oh J,Takahashi R,et al.RECK:a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling[J].Cancer Metastasis Rev,2003,22(3):167-175.
  • 8Noda M,Takahashi C.Recklessness as a hallmark of aggressive cancer.Cancer Sci.2007.98(11):1659-1665.
  • 9Meng N,Li Y,Zhang H,et al.RECK,a novel matrix metalloproteinase regulator[J].Histol Histopathol,2008,23(8):1003-1010.
  • 10郝斌,张波.RECK、MMP-9在膀胱移行细胞癌组织中的表达及其意义[J].山东医药,2008,48(26):21-22. 被引量：1

共引文献6

同被引文献34

  • 1王兵,楼晓楼,刘文勇,蒋米尔,林梅绥,胡庆沈.PTEN蛋白在乳腺癌中表达的研究[J].中国临床医学,2007,14(6):887-889. 被引量：1
  • 2De Aminis F, Aquila S,Morelli C,et al.Bergapten drives autophagythrough ihe up-reguladon of PTEN expression in breast cancer cells [ J ].Mol Cancer,2015,14( 1):130.
  • 3Heindl LM,Schrodl F,Liitjen-Drecoll E,et al.Ciliary body lym-phangiogenesis[ J].Ophthalmology ,2013,120(7) :e41 -42.
  • 4Choi Y,Park KJ,Ryu S,et al.Papillary thyroid carcinoma involvingcervical neck lymph nodes : correlations with lymphangiogenesis andultrasound features[j].Endocr J,2012,59( 10) :941-948.
  • 5Royston D,Jackson DG.Mwhanisms of lymphatic metastasis in humancolorectal adenocarcinnma[ J] J Pathol,2009,217(5 ) :608-619.
  • 6Tammela T, Alitalo K.Lymphangiogenesis: molecular mechanisms an(lfuture promise[j ].Cell, 2010,140(4) :460-476.
  • 7Qazi H,Palomino R,Shi ZD,et al.Canrer cell glycocalyx mediatesmechanotransduc-tion and flow-regulated invasion[j].Integr Biol(Camh),2013,5(11): 1334-1343.
  • 8Alita]o A,Detmar M.Interaction of tumor cells and lymphatticvessels in cancer progression [ J ].Oncogene, 2012,31 ( 42 ) : 4499-4508.
  • 9Krehs R ,Tikkanen JM,Ropponen J0,et al.Critical role of VE(;F-C/VEGFR-3 signalinging in innate and adaptive immune responsesin experimental ohliterative hronr-hiolil is [ J J .Am J Pathol,2012,181(5):1607-1620.
  • 10Stacker SA,Achen MG.From anti-angiogenesis to anti-lymphangio-genesis :emerging trends in canrer lherapy[j ].Lymphat Res Bi“l,2008,6(3-4):165-172.

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中国实用口腔科杂志
2013年 第10期

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