中老年男性不同糖耐量状态下骨钙素水平变化及与糖脂代谢的关系

Relevance between the serum osteocalcin and glucose and lipid metabolism in middle-aged men with different glucose tolerance

目的探讨血清骨钙素(OC)在中老年男性不同糖耐量状态下的水平变化以及与糖脂代谢相关性。方法将80例受试者根据口服葡萄糖耐量实验结果分为正常糖耐量(NGT)组、糖耐量受损(IGT)组和2型糖尿病(T2DM)组,比较不同组间各代谢指标及空腹血清OC的差异。结果 OC在NGT组与IGT组及T2DM组内呈递减趋势(P<0.01);OC与体质量指数、腰臀比(WHR)、空腹血糖、餐后2小时血糖(2hPG)、胰岛素抵抗指数(HOMA-IR)、胆固醇、三酰甘油(TG)及收缩压呈负相关,与脂联素呈正相关(P<0.05,P<0.01);WHR、HOMA-IR、2hPG、TG为OC的独立相关因素(P<0.05)。结论 OC可能参与胰岛素抵抗,与糖脂代谢密切相关。

Objective To investigate the serum osteocalcin（ OC ） state at different levels of impaired glucose tolerance and the relevance between the serum osteocalcin and the metabolic indicators. Methods Sixty cases of mid- dle-aged male groups according to oral glucose tolerance test group were divided into normal glucose tolerance group （NGT）, impaired glucose tolerance group （IGT） and type 2 diabetes group （T2DM）, comparing different groups of various metabolic indicators and the differences in fasting serum OC. Results OC in the NGT group and IGT group and the T2DM group decreased significantly （P 〈 0.01 ） ; serum OC levels correlated with adiponectin,negatively with body mass index,waist-hip ratio（ WHR）, fasting plasma glucose （FPG） ,2 hour plasma glucose after glucose load （2hPG）, homeostasis model assessment insulinresistance index（ HOMA-IR）, total cholesterol （TC）, triglyeride （TG）（P 〈0.01 and P 〈0.05） in simple regression analysis. OC is the independent relevant factors of WHR,HOMA-IR,2hPG,TG （P 〈 0.01 ）. Conclusion OC may be involved in insulin resistance, and is closely related to glucose and lipid metabolism.