热敷对降低奥沙利铂化疗致神经毒性反应的效果

Effect of hot compress on reducing oxaliplatin-induced neurotoxicity

目的探讨热敷对降低奥沙利铂化疗致神经毒性反应的效果。方法将120例应用奥沙利铂联合希罗达方案化疗的肿瘤患者随机分为对照组和实验组,每组各60例,对照组按常规方法进行健康指导,实验组在此基础上采取热敷疗法。分别比较化疗完成2、4个疗程后神经毒性反应发生率。结果实验组第2个疗程结束后神经毒性发生率为75.0%,对照组为91.7%;实验组第4个疗程结束后神经毒性发生率为86.7%,对照组为98.3%,两组比较,均P<0.001,差异具有统计学意义。结论热敷能有效减低奥沙利铂化疗过程致神经毒性的发生率。

Objective To observe the effects of hot compress on oxaliplatin-induced neurotoxicity. Methods One hundred and twenty patients undergoing chemotherapy with oxaliplatin enrolled in this study were randomly assigned to the control group and expenment group. The control group was given routine health education and the experiment group was treated with hot compress. We compared the incidence of nerotoxocity after 2 and 4 treatment courses. Resulsts The incidence of neurotoxiticity was 75.0% in the experiment group and 91.7% in the control group after 2 treatment courses （P 〈 0.01）. The incidences were 86.7% in the experiment group and 98.3% in the control group after 4 treatment courses （P 〈 0.001）. Conclusion Hot compress can effectively reduce the incidence of neurotoxicity induced by chemotherapy with oxaliplatin.