双氯芬酸钠微乳凝胶的研制与体外透皮性能的初步考察

Preparation and Preliminary Investigation of in vitro Transdermal Property of Diclofenac Sodium Microemulsion-based Hydrogel

比较了卡波姆980、羟丙甲纤维素(1×104mPa·s)和Sangelose 90L作为双氯芬酸钠微乳水凝胶基质的效果。结果仅以卡波姆980为骨架材料时可得到金黄色透明的微乳凝胶。该制品黏度为(6 000±2.65)mPa·s,pH值为6.5±0.5,稳定性较好。继续以小鼠离体皮肤为模型考察其体外透皮特性,并与市售凝胶对比。结果表明,自制微乳凝胶12 h累积透过量高于市售凝胶,稳态渗透速率为(20.08±0.73)g·cm-2·h-1,明显高于市售凝胶[(9.47±0.41)g·cm-2·h-1]。

The effects of three kinds of matrix, carbopol 980, HPMC （1×104 mPa·s） and Sangelose 90L, for diclofenac sodium microemulsion-based hydrogel were compared. The results showed that the transparent yellow microemulsion-based hydrogel was only available with carbopol 980 as a substrate. The viscosity and pH value of the product were （6 000±2.65） mPa.s and 6.5±0.5, respectively. The product was also rather stable. The in vitro transdermal property through excised mouse skin was investigated. Compared with the commercial hydrogel, the cumulative amount at 12 h of the microemulsion-based hydrogel was higher. The steady-state penetration rate of microemulsion-based hydrogel was （20.08±0.73） μg·cm-2·h-1, which was higher than that of commercial hydrogel [ （9.47±0.41） μg·cm-2·h-1].