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微针在透皮给药系统研究中的进展 被引量：4

Progress of Microneedles in Transdermal Drug Delivery System
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摘要 皮肤角质层的屏障作用限制了大分子、水溶性药物在透皮给药系统中的应用,而提高被动扩散动力和使用促渗剂较难达到理想的效果。微针用于促进药物的透皮传递,特别是用于大分子药物及透皮免疫的研究已成为一个热点。本文在对近年来国内外文献调研的基础上综述了微针用于透皮给药系统的研究状况,包括微针的概念、类型及特点、影响药物通过微针透皮的因素和应用等。 The barrier function of the stratum corneum of skin limits the usage of macromolecular and hydrophilic drug in transdermal drug delivery system （TDDS）. Through traditional passive diffusion dynamic way or adding penetration enhancers, the cumulative penetrative can be increased, but it may hardly reach an ideal effect. The investigation of microneedles in TDDS is one of the hot spots at present, especially in the field of macromolecular drug and transeutaneous immunization （TCI）. Based on the domestic and foreign literatures in recent years, current status of microneedles application to TDDS is summarized. The conception, classification, characteristics, influence effects on microneedle-based transdermal drug delivery system and applications are introduced in this paper.
作者 卢望丁 罗华菲 张晓红 朱壮志 王浩
机构地区 中国医药工业研究总院药物制剂国家工程研究中心 中国医药工业研究总院药上海现代制药股份有限公司
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2013年第11期1154-1159,共6页 Chinese Journal of Pharmaceuticals
基金 国家“重大新药创制”科技重大专项(2012ZX09304004)
关键词 透皮给药 微针 透皮免疫 综述 transdermal drug delivery system microneedle transcutaneous immunization review
分类号 R944.9 [医药卫生—药剂学]
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参考文献28

  • 1Thomas BJ, Finnin BC. The transdermal revolution [J].Drug Discov Today, 2004, 9(16): 697-703.
  • 2Henry S, McAllister DV, Allen MG, et al. Microfabricatedmicroneedles: a novel approach to transdermal drug delivery[J]. J Pharm Sci, 1998, 87 (8): 922-925.
  • 3Herwadkar A,Banga AK. Peptide and protein transdermaldrug delivery [J]. Drug Discov Today Technol, 2012, 9 ⑵:el47-el54.
  • 4Hegde NR, Kaveri SV, Bayry J. Recent advances inthe administration of vaccines for infectious diseases:microneedles as painless delivery devices for mass vaccination[J]. Drug Discov Today,2011,16 (23-24): 1061-1068.
  • 5Matsuo K,Hirobe S, Yokota Y, et al. Transcutaneousimmunization using a dissolving microneedle array protectsagainst tetanus, diphtheria, malaria, and influenza [J]. JControlled Release, 2012,160 (3): 495-501.
  • 6van der Maaden K, Jiskoot W, Bouwstra J. Microneedletechnologies for (trans) dermal drug and vaccine delivery [J].J Controlled Release, 2012,161 (2): 645-655.
  • 7Milewski M,Yerramreddy TR,Ghosh P, et al. In vitropermeation of a pegylated naltrexone prodrug acrossmicroneedle-treated skin [J]. J Controlled Release, 2010,146(1):37-44.
  • 8Gomaa YA, Morrow DI, Garland MJ, et al. Effects ofmicroneedle length, density, insertion time and multipleapplications on human skin barrier function: assessments bytransepidermal water loss [J]. Toxicol In Vitro, 2010,24(7):1971-1978.
  • 9Brogden NK, Milewski M, Ghosh P, et al. Diclofenac delaysmicropore closure following microneedle treatment in humansubjects [J]. J Controlled Release, 2012,163 (2): 220-229.
  • 10Vrdoljak A, McGrath MG, Carey JB, et al. Coatedmicroneedle arrays for transcutaneous delivery of live virusvaccines [J]. J Controlled Release ^ 2012,159(1): 34-42.

二级参考文献39

  • 1LIN L, PISANO A P. Silicon-Processed Microneedles [J] .IEEE Journal of Microelectromechanical Systems, 1999, 8(1): 78-84.
  • 2OKA K, AOYAGI S, ISONO Y, et al. Fabrication of a microneedle for a trace blood test [J] . Sensors and Actuators A, 2002, 97-98: 478-485.
  • 3PAIK S J, LIM J M, JUNG I, et al. A novel microneedle array integrated with a PDMS biochip for microfluid systems[A] . The 12th International Conference on Solid State Sensors, Actuators and Microsystems [C] . Boston: 2003. 1446-1449.
  • 4PAIK S J, BYUN S, LIM J M, et al. In-plane single-crystal-silicon microneedles for minimally invasive microfluid systems [J] . Sensors and Actuators A: Physical, 2004, 114(2-3): 276-284.
  • 5TALBOT N H, PISANO A P. Polymolding: Two wafer polysilicon micromolding of closed-flow passages for microneedles and microfluidic devices [ A] . Tech. Dig. Solid-State Sensor and Actuator Workshop Hilton Head [C] . S C, USA,1998. 265-268.
  • 6BRAZZLE J D, PAPAUTSKY I, FRAZIER A B. Fluid-coupled hollow metallic micromachined needle arrays [J] . Proc.SPIE, Microfluidic Devices and Systems, 1998, 3515: 116-124.
  • 7BRAZZLE J D, PAPAUTSKY I, FRAZIER A B. Micromachined needle arrays for drug delivery or fluid extraction [J] .IEEE Eng Med Biol Mag, 1999, 18: 53-58.
  • 8PAPAUTSKY I, BRAZZLE J, SWERDLOW H, et al. Micromachined pipette arrays [J] . IEEE Transactions on Biomedical Engineering, 2000, 47 (6): 812-819.
  • 9CHANDRASEKARAN S, FRAZIER A B. Mechanical characterization of surface micromachined microneedle array [ A] .2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine & Biology [C] . Madison,Wisconsin, 2002. 94-98.
  • 10CHANDRASEKARAN S, FRAZIER A B. Characterization of surface micromachined hollow metallic microneedles [A], Proc.16th Annu Int Conf MICRO Electro MECHANICAL Systems[C] . Kyoto, Japan, 2003. 363-366.

共引文献11

同被引文献29

引证文献4

二级引证文献26

中国医药工业杂志
2013年 第11期

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