青年人原发性肝癌致病因素配对病例对照研究

A matched case control study on the pathogenic factors of primary hepatocellular carcinoma among the youth

目的 :调查湛江市青年人原发性肝癌 (PHC)的病因。方法 :对 1 2 0例青年人原发性肝癌患者采用病例 -对照研究。结果 :湛江市青年人原发性肝癌与乙型肝炎病毒 (HBV)感染密切相关 ,HBV总感染率为 79.5% ,明显高于对照组 1 9.5% (P<0 .0 1 )。肝癌家族史、肝炎史、饮水、饮酒为青年人原发性肝癌主要危险因素。结论

Objective:To investigate the pathogenic factors of primary hepatocellular carcinoma(PHC)among the young people in Zhanjiang City.Methods:One hundred and twenty paris young patients with PHC were selected for 1:1 case control study.Results:The rick factor of PHC was closely related to HBV infection.The total of rate for HBV infection in the patients with PHC was much higher than that of non PHC(79.5% vs 19.5, P <0.01).The family histories of hepatoma and of hepatitis,drinking water and alcohol were also related to PHC.Conclusion:HBV infection might be a major risk factor of PHC among young people.