大黄素抗炎作用及对急性肺损伤治疗作用研究进展

The Research Progress on Anti-inflammatory Effects and the Therapy to Acute Lung Injury of Emodin

[目的]探讨大黄素抗炎作用及其对急性肺损伤的治疗作用。[方法]通过查阅PUBMED、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库和维普数据库汇总1998—2012年间的相关文献,总结归纳大黄素的抗炎作用和机制,以及其对急性肺损伤的治疗作用。[结果]多种体内外研究都证实大黄素具有抗炎作用,其抗炎机制与抑制NF-κB活化、调节多种炎症因子等相关。另外,大黄素对急性肺损伤的治疗作用在细胞及动物水平得到肯定。[结论]大黄素有良好的临床应用前景。

[Objective] To explore the anti-inflammatory effects of emodin and its therapeutic effect on acute lung injury. [Methods] By means of analyzing the relevant literatures in PUBMED,CNKI,CBM,Wanfang and Vip Da-tabase from 1998 to 2012,summarized the anti-inflammatory effects and mecha-nisms of emodin, as wel as its therapeutic effect on acute lung injury. [Results] A variety of studies have confirmed the anti-inflammatory effects of emodin, whose mechanism is related to emodin inhibiting the activation of NF-kappa B,modulaing various inflammatory factors, etc. In addition, the effect of emodin in the treatment of acute lung injury has been confirmed on celland animal levels. [Conclusion] Emodin has good prospect of clinical application.