窒息新生儿血浆β-EP、β2-MG值变化与脑、肾损伤的关系

Relationship between the changes of β EP\,β\-2 MG's concentrations in serum after asphyxia neonate and hypoxia cerebral damage and renal damage

目的 :探讨新生儿窒息后血浆β-内啡呔 (β- EP)、β2 -微球蛋白 (β2 - MG)浓度的变化与脑、肾损伤的关系。方法 :用放射免疫法监测窒息新生儿重度组 15例、轻度组 12例和对照组 10例血浆β- EP、β2 - MG的浓度 ,分别于生后 8～ 12 h、72～ 96 h采血两次。 结果 :窒息组 β- EP、β2 - MG值均明显增高 ,经方差分析各组间存在总体差异 (P<0 .0 1～ 0 .0 0 1)。经 q检验 ,8～ 12 h轻度组与对照组比较 ,P <0 .0 1～ 0 .0 0 1;重度组与轻度组比较 ,P <0 .0 0 1。脑病组与非脑病组 β- EP值比较 ,P <0 .0 0 1。 结论 :新生儿窒息可致 β- EP、β2 - MG值增高 ,且与窒息程度有关。 β-EP可能参与并加重了脑损伤的病理生理过程。β2 - MG的浓度变化 ,对早期反映窒息后引起肾小球滤过率障碍较为敏感 。

Objective: To study the relationship between the changes of β EP\,β\-2 MG's concentrations in serum after asphyxia neonate and hypoxia cerebral damage (HCD) and renal damage. Methods: 15 serious cases and 12 mild cases with 10 cases as control group were tested on concentrations of β EP\, β\-2 MG in serum by the method of radio immunity. They were separately tested in 8～12 h and 72～96 h after birth. Results: The β EP\,β\-2 MG values of asphyxia group were obviously risen, there were total difference among each group by analysis of variance P<0.01～0.001. In 8～12 h there were significant difference between the mild asphyxia group and the cntrol group P<0.01～0.001, the same difference as between the serious cases and the control group P<0.001. There were very significant difference between the HCD group and the nonHCD group P<0.001. Conclusion: Asphyxia may lead to the rise of β EP\,β\-2 MG's concentration in serum, which is correlated with the degree of asphyxia. β EP may take part in the pathological and physiological processes of HCD. The change of β\-2 MG's concentration was sensitive to reflect the obstacle of glomerular filtrative rate in early phase, and it is correlated with the degree of renal damage.