准分子激光角膜切削术后角膜上皮下混浊与术前总屈光度的关系

Haze following Excimer Laser Photorefractive Keratectomy and Full-Refraction Prior to PRK

目的 :探讨准分子激光角膜切削术 (photorefractivekeratectomy ,PRK)后角膜上皮下混浊 (Haze)与术前眼总屈光度之间的关系。方法 :将接受PRK手术患者近视和散光的总屈光度分成低度 (- 1.0 0～ - 3.0 0D)、中度 (- 3.2 5～ - 8.0 0D)、高度 (- 8.2 5～ - 16 .0 0D以上 )三组 ,同时对高度组中的角膜水化与非角膜水化进行统计 ,比较术后角膜Haze形成情况。结果 :低度组和中、高度组比较发生角膜Haze的程度差异有显著性 (P <0 .0 1) ,而中度组和高度组比较差异无显著性 (P >0 .0 5 ) ,术中角膜水化组与非水化组发生角膜Haze比较具有显著性差异 (P <0 .0 5 )。结论 :PRK术后Haze形成与术前治疗总屈光度之间没有正相关系 ,术后科学有效地使用皮质类固醇激素和辅助用药以及对高度近视眼治疗过程中进行角膜水化作用是减少Haze形成的有效方法。

Objective To explore the connection between the Haze after Excimer Laser photorefraction Keratectomy and Full-Refraction Before PRK. Methods 298 cases(579 eyes) undergoing PRK full-reffraction, including myopia and astigmatism, were divided into three groups: mild (-1.00～-3.00D), moderate (-3.25～ -8.00 D),severe (-8.25～-16.00D).The severe group(170 eyes) was subdivided into two groubs:76 eyes washed with Ringer's solution during operation (the treatment group); 94 eyes unwashed (the control group). All the data were statistically analyzed. The follow-up was 6～12 months (average 8 month).Results The comparative analysis showed no significant differences between the three groups(P<0.01) and between the treatment and control groups (P>0.05).Conclusion There is no relationship between Haze after operation and full-refraction before operation. The scientific and effective use of corticosteriod and other drugs, and cornea watering as a supplementary treatment will reduce the formation of Haze.