ICAM-1基因Gly214Arg多态性与缺血性脑卒中的关系

Relationship between ICAM-1 Gene Gly 214Arg Polymorphism and Ischemic Stroke

目的 探讨中国人缺血性脑卒中与细胞间粘附分子 1(IntercellularAdhesionMolecule 1,ICAM 1)基因Gly 2 14Arg多态性之间的关系。方法 利用PCR技术和分子杂交技术对北京地区 2 94例缺血性脑卒中患者进行ICAM 1基因Gly2 14Arg多态性的检测和分析 ,并与 2 79例北京地区的非卒中对照进行比较。 结果 缺血性脑卒中患者ICAM 1基因Gly2 14Arg多态性的基因型频率和等位基因频率与对照组相比无明显差异。结论 ICAM 1基因Gly 2 14Arg多态性可能不是中国人群缺血性脑卒中发病的遗传学危险因素。

Objective To investigate whether ICAM-1 gene Gly 214Arg polymorphism is associated with ischemic stroke in Chinese people.Method ICAM-1 gene Gly 214Arg polymorphism was determined by polymerase chain reaction(PCR) and molecular hybridization in 294 patients with ischemic stroke and 279 controls selected from Beijing population.Two groups were matched in sex,age and blood pressure.Results The prevalence rates of genotype and allele frequency of ICAM-1 gene Gly 214Arg polymorphism are not significantly different between ischemic stroke group and control group( P >0.05).Conclusion ICAM-1 gene Gly214Arg polymorphism is not associated with ischemic stroke.