铜对动物超氧化物歧化酶活性的影响及可能的作用途径

Effect of copper on the superoxide dismutase activity in animals and it's possible mechanism

超氧化物歧化酶是动物体内重要的抗氧化酶,对清除多余的自由基起着重要作用,而这一功能主要是通过铜锌超氧化物歧化酶和锰超氧化物歧化酶实现的。铜可能直接或间接地影响铜锌超氧化物歧化酶的活性,而铜缺乏引起的活性氧变化则可能通过转录因子NF-κB和AP-1调控锰超氧化物歧化酶的表达。

Superoxide dismutase is an important antioxidant enzyme in animals and plays an important role to remove excess free radicals which achieved mainly through the copper-zinc superoxide dismutase and manganese superoxide dismutase. Copper may directly or indirectly affect the copper-zinc superoxide dismutase activity, while the change of reactive oxygen species induced by copper deficiency may regulate manganese superoxide dismutase expression through the transcription factor NF-κB and AP-1.