全氟辛烷磺酸神经发育毒性机制研究进展

Research Progress on Mechanisms in the Developmental Neurotoxicity of PFOS

全氟辛烷磺酸(PFOS)是全氟化合物的终端降解产物,在生态环境中能够通过食物链进入生物组织并蓄积,对环境和生物存在潜在危害。动物实验研究发现,PFOS能够通过胎盘和血脑屏障,影响发育期神经系统,其持续性和严重性已引起国内外学者的广泛关注。本文通过对PFOS神经发育毒性效应及其主要机制研究进展进行综述,分析目前研究现状,并对未来PFOS神经发育毒性机制研究提出设想和展望。

Perfluorooctane sulfonates （PFOS）, the terminal degradation products ofperfluorinated compounds, can bioaccumulate through food chains and is regarded as a potential threat to our riving environment. Stud- ies in animals have shown that PFOS passes through placental barrier and blood brain barrier, and induces toxic effects in central nervous system （CNS）. In particular, PFOS induces developmental neurotoxicity, and its severity and persistency have been widely recognized. In this current article, we thoroughly reviewed the de- velopmental neurotoxicity by in vivo and in vitro exposure to PFOS and its underlying mechanisms. Further- more, we discussed present problems in this area and put forward suggestions on future research.