白细胞介素-8在鼻息肉中的免疫组化研究

Immunohistochemical study of interleukin-8 in human nasal polyps

目的 探讨鼻息肉中白细胞介素-8（IL-8）免疫反应阳性物质在鼻息肉中的分布和表达。方法 应用免疫组化技术(SABC法)检测32例鼻息肉和12例正常对照组下鼻甲前端粘膜组织内IL-8免疫阳性物颗粒的分布和表达。结果 鼻息肉中IL-8免疫阳性物质存在且主要分布在鼻息肉上皮层和嗜酸性粒细胞的细胞浆内；对照组中，上皮层细胞浆有少量的IL-8免疫阳性颗粒着色。结论 IL-8与鼻息肉的形成有重要的关系。

Objective To investigate the distribution and expression of immunoreactive interleukin-8 (IL-8) in the human nasal polyps. Methods Thirty-two specimens of nasal polyp and 12 specimens of normal inferior turbinate were studied with immunohistochemistry SABC method. Results IL-8 antigen staining was observed predominantly in the acidophilic and the epithelium cells in the nasal polyps, and immunoreactive IL-8 was distributed widely in the cell plasm of these cells, and IL-8 antigen staining was barely observed in control. Conclusion IL-8 may play a significant role in the pathogenesis of nasal polyps.