大面积深度烧伤后广谱高效抗生素早期短程使用的临床疗效

Early use of high-potency antibiotics within short courses: a prospective clinical study

目的 探讨大面积深度烧伤后广谱高效抗生素早期短程使用的效果。方法 将同一时期收治的17名患者随机分成抗生素短程用药组（EUS）和传统用药组（TUC），比较在全身使用泰能和丁胺卡那霉素情况下两组的抢救成功率，血中细菌培养发生率以及体温，白细胞总数，血小板计数等与感染密切相关的指标。结果17名患者均成活，且无一例血培养细菌阳性者，两组体温、白细胞总数、血小板计数均无显著性差异（P>0.05）。结论 观察结果表明，大面积深度烧伤后，早期短程的广谱高效抗生素冲击治疗，既节省费用，又有效地防治了全身性感染。

Objective To evaluate the effect of early and short-term use of high-potency antibiotics following extensive severe burn injury. Methods Seventeen severely burned patients hospitalized in the same period (Nov, 1998 to Oct, 2000) were randomly divided into 2 groups. Patients in group 1 received early treatment with imipenum and amikacin for 5 d, and the same treatment in group 2 was discontinued on day 15 postburn. The survival rate, blood bacterial culture, body temperature and white blood cell and platelet counts were compared between the 2 groups. Results All the 17 patients survived and all blood bacterial cultures were negative. No significant difference in the body temperature or white blood cell and platelet counts between the 2 groups was observed (P>0.05). Conclusion Early use of high-potency antibiotics at a short treatment course after extensive severe burn is effective to prevent infection and reduce the cost.