急性冠状动脉综合征患者血小板活化状态的探讨

Study of Platelet Activation in Acute Coronary Artery Syndrome

目的 :探讨血小板表面膜蛋白颗粒 (GMP - 140 )的增高是否反映了血小板的激活和释放反应。方法 :对 45例急性冠状动脉综合征 (ACAS)患者 ,其中 19例急性心肌梗死 (AMI)和 2 6例不稳定型心绞痛 (UAP) ,进行血浆GMP - 140、假血友病因子 (vWF)测定。结果 :AMI和UAP患者血浆GMP - 140、vWF明显升高。GMP - 140与血清肌酸激酶及其同功酶、乳酸脱氢酶及其同功酶以及心肌梗死和心绞痛缺血面积均呈正相关。结论 :血清GMP -

Objective:To study whether the platelet α-granule membrane protein(GMP-140) is a specific index of platelet activation and GMP-140 of plasma can reflect the platelet activation.Methods:The number of GMP-140 and von Willebrand Factor(vWF)of plasma were determined in 45 patients with acute coronary artery syndrome (19 with AMI and 26 with UAP).Results:The number of GMP-140 and vWF of plasma in patients with ACAS(AMI and UAP)were significantly higher than that of normal controls(P<0.01).The data showed the positive correlation between GMP-140、CK、CK-MB、LDH、HBDH and ischemic.(or infarction) size.Conclusion:GMP-140 of plasma may be important index to evaluate platelet activation.