摘要
目的 :研究来氟米特的透皮特性和脂质体对此的影响。方法 :采用改良 Franz扩散池 ,以离体皮肤为渗透屏障 ,渗透系数为指标 ,HPL C法测定来氟米特浓度。结果 :来氟米特本身具有较好的皮肤渗透性能 ,脂质体对来氟米特的皮肤渗透性能影响不大。 结论 :来氟米特可以采用经皮肤局部给药的方式给药。
Objective: To study the permeability of leflunomide and the effect of liposome on its permeability. Methods: Modified Franz diffusion cell adopted as apparatus for in vitro skin permeation. Various excised skins were used as permeation barriers and permeation coefficient was used as index. The concentration of leflunomide in the samples was measured by HPLC. Results: Leflunomide had a good permeability, but the effect of liposome on permeability was not very strong. Conclusion: It is feasible that leflunomide is applied through skin. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第10期971-974,共4页
Academic Journal of Second Military Medical University
基金
全军"九五"医学科研规划基金资助项目!(98M0 77)
关键词
来氟米特
脂质体
透皮吸收
leflunomide
liposome
percutaneous absorption