绝经后2型糖尿病女患者血清维生素D水平

Serum vitamin D levels in postmenopausal women with type 2 diabetes mellitus

目的:研究绝经后女性2型糖尿病(T2DM)患者血清25-羟基维生素D3[25(OH)D3]的水平与糖脂代谢指标的关系。方法:研究对象为44例绝经后女性T2DM患者,对照组为41例年龄、体质量指数(body mass index,BMI)及绝经年限匹配的健康绝经后女性。ELISA测定血清25(OH)D3水平。结果:T2DM组血清25(OH)D3水平低于对照组,但无明显统计学差异(P=0.372);正常绝经后女性血清25(OH)D3多元线性回归分析提示,BMI与25(OH)D3呈独立负相关关系(r=–0.372,P<0.05);所有绝经后女性研究对象中有84.7%存在维生素D缺乏,其中对照组中有80.5%存在维生素D缺乏,T2DM组中有88.6%存在维生素D缺乏。T2DM组维生素D缺乏的发生率高于正常女性,但差异无统计学意义(P=0.372)。在所有绝经后女性研究对象中,二元Logistic回归分析发现25(OH)D3不是T2DM发病的危险因素。结论:T2DM组血清25(OH)D3水平低于对照组,血清25(OH)D3缺乏的患病率高于对照组,但在校正BMI后差异无统计学意义。在绝经后女性中,维生素D下降与肥胖及血脂代谢异常密切相关,与糖尿病的发生无明显相关性。

Objective： To investigate the correlation between serum vitamin D levels and index of glucose and lipid metabolism in postmenopausal women with type 2 diabetes mellitus （T2DM）. Methods： A total of 44 postmenopausal women with T2DM and 41 healthy postmenopausal women were matched with age, body mass index and menopausal duration. ^-he serum vitamin D was detected by enzyme-linked immuno-sorbent assay （ELISA）. Results： Compared with the control group, the level of25（OH）D3 in postmenopausal women with T2DM was lower, with no statistical significance. Multiple regression analysis revealed that onlyBMI（b/=-0.372, P〈0.05） was independently related to 25（OH）D3 with statistical significance. The percentages of 25（OH）D3 deficiency in all subjects in the control group and in the T2DM group were 84.7%, 80.5%, and 88.6%, respectively. The 25（OH）D3 deficiency in the T2DM group was more prevalent than that in the control group, with no statistical differece （P=0.372）. The binary logistic regression analysis showed the serum 25（OH）D3 level was not related to the risk of diabetes. Conclusion： Compared with the control group, a lower 25（OH）D3 level and a higher rate of 25（OH）D3 deficiency is found in T2DM subjects. When rectified by BMI, these is no significant difference. In postmenopausal women, hypovitaminosis D is associated with obesity and dyslipidemia, but not with the risk of T2DM.