摘要
摘要目的评价中国地区糖尿病对乳腺癌患者预后的影响。方法检索1991～2012年CNKI、万方、维普、Pubmed、EMBASE等数据库，收集有关糖尿病影响乳腺癌患者预后的病例对照研究。以单纯乳腺癌组与乳腺癌合并糖尿病组预后差异的OR值为效应指标，经一致性检验后进行OR合并，并进行偏倚评估。采用Revman5．0软件进行Meta分析。结果符合纳入标准的论文共6篇，包括5487例患者。Meta分析结果显示，糖尿病影响乳腺癌患者的5年无病生存[OR=2．4，95％CI（1．67，3．46）]和5年总生存[OR=2．14，95％CI（1．66，2．77）]。结论糖尿病会降低中国地区乳腺癌患者的5年无病生存及5年总生存，使乳腺癌患者预后不佳。糖尿病可能是女性乳腺癌的一个潜在预后不良的因素。
Objective To evaluate the influence of diabetes mellitus on the prognosis of breast carcinoma in China. Methods We conducted a meta analysis of case - control studies to assess the evidence regarding to the association between diabetes and prognosis of breast cancer. Studies were＇indentified through searching database including CNKI, Wanfang, Weipu, Pubmed and EMBASE, and the references of retrieved articles. Then apply meta analysis using Revman 5. O. Results Six studies with 5487 cases of patients were inden- tified according to inclusion criteria. In this metaanalysis, breast cancer patients with diabetes mellitus had significantly shorter 5 - year disease free survival[ OR = 2.4,95 % CI （ 1.67,3.46 ） ] and the overall 5 - year survival [ OR = 2.14,95 % CI （ 1.66,2.77 ） ] compared with their nondiabetic counterparts. Conclusion Diabetes can shorten both the 5 - year disease free survival and the overall 5 - year sur- vival of breast cancer patients in China, resulting in a worse prognosis.
出处
《医学研究杂志》
2013年第10期99-102,共4页
Journal of Medical Research
关键词
糖尿病
乳腺癌
预后
META分析
Diabetes me｜litus
Breast cancer
Prognosis
Meta analysis
