小剂量硼替佐米联合T-VAD方案治疗老年多发性骨髓瘤八例报告
被引量:1
摘要
多发性骨髓瘤(multiple myeloma,MM)呈逐年增高趋势。临床上治疗〉70岁患者仍是一个难题,因为随着年龄的增长,各重要脏器功能逐渐下降,并常伴有其他基础疾病,个体情况差异较大,对药物治疗耐受性差,更需不断探讨有效的个体化方案。本研究采用小剂量硼替佐米联合T-VAD方案治疗〉70岁初诊MM患者8例。
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第21期1697-1698,共2页
Chinese Journal of Cancer Prevention and Treatment
参考文献11
-
1陈世伦,于力,邱录贵.多发性骨髓瘤诊疗常规[M].北京:人民卫生出版社,2012:61-62.
-
2Durie BG,Harousseau JL,Miguel JS,et al. International uniform response criteria for multiple myeloma[J]. Leukemia, 2006,20 (9) : 1467-1473.
-
3Anderson KC, A|sina M,Bensinger W,et aL NCCN clinical prac- tice guidelines in oncology multiple myeloma [J]. J Natl Compr Canc Netw,2013,11(1) :11- 17.
-
4Mateos MV, Oriol A, MartinevL6pez J, et aL Bortezomib, melphalan, and prednisone versus bortezomib,thalidomide, and prednisone as in duction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple myeloma:a randomised trial [J]. Lancet On- col,2010,11(10) : 934-941.
-
5Fukushima T,Nakamura T,Iwao H,et al. Efficacy and safety of bortezomib plus dexamethasone therapy for refractory or re lapsed multiple myeloma: once-weekly administration of borte- zomib may reduce the incidence of gastrointestinal adverse events [J]. Anticancer Res,2011,31(6):2297-2302.
-
6康岩,赵月莹,郭梅,余长林,乔建辉,胡锴勋,孙琪云.减低剂量的硼替佐米治疗老年性多发性骨髓瘤临床研究[J].第二军医大学学报,2012,33(10):1142-1144. 被引量:7
-
7苏基滢,周立宇,徐黎,宋陆茜,张曦,肖超,常春康.偏小剂量的硼替佐米联合地塞米松治疗初发多发性骨髓瘤疗效观察[J].癌症进展,2012,10(1):80-83. 被引量:9
-
8张伟,张岩.硼替佐米治疗多发性骨髓瘤的临床观察[J].中华肿瘤防治杂志,2010,17(17):1368-1370. 被引量:9
-
9Morabito F,Gentile M, Mazzone C, et al. Safety and efficacy of bortezomih-melphalan prednisone-thalidomide followed by borte zomib-thalidomide maintenance (VMPT-VT) versus bortezomib melphalan-prednisone(VMP) in untreated multiple myeloma pa- tients with renal impairment I-J]. Blood, 2011,118 ( 22 ) : 5759-5766.
-
10Richardson PG,Sonneveld P,Schuster M, et al. Extended follow up of a phase 3 trial in relapsed mutiple myeloma:final time to e- vent results from the APEX trial[J]. Blood, 2007, 110(10): 3557- 3560.
二级参考文献27
-
1吕晓芳,于世英,冷彦.骨代谢生化指标在恶性肿瘤骨转移诊断中的价值[J].中国肿瘤临床,2007,34(3):154-156. 被引量:12
-
2刘桐宇,叶建新.蛋白酶体抑制剂治疗多药耐药肿瘤机制的研究进展[J].中华肿瘤防治杂志,2007,14(15):1187-1190. 被引量:6
-
3Bross P F, Kane R, Farrell A T, et al. Approval summary for bortezomib for injection in the treatment of multiple myeloma [J]. Clin Cancer Res, 2004, 10(12): 3954.
-
4Jagannath S, Richardson P G, Barlogie B, el al. Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezomib alone[J]. Haematologica, 2006, 91 :929-934.
-
5Jagannath S, Durie B G, Wolf J, et aI. Bortezomib therapy alone and in combination with dexamethasone for previously un treated symptomatic multiple myeloma[J]. Br J Haematol, 2005 129(6) : 776-783.
-
6Richardson P G, Barlogie B, Berenson N J, et al. A phase 2 study of bortezomib in relapsed,refractory myeloma[J]. N Engl J Med,2003,348 : 2609-2617.
-
7Davies F E, Wu P, Jenner M, et al. The combination of cyclophosphamide,velcade and dexamethasone induces high response rates with comparable toxicity to velcade alone and velcade plus dexamethasone[J]. Haematologica,2007,92(8) :1149 -1150.
-
8Evangelos T, Athanasios A, Efstathios K, et al. The combination of bortezomib, meiphalan, dexamethasone and intermittent thalidomide (VMDT) is an effective treatment for relapsed/refractory myeloma: Results of a phase clinical trial[J]. Blood, 2005, 106: 363.
-
9Chanan-Khan A A, Miller K C, McCarthy P, et al. A phase II study of Veleade (V). Doxil (D) in combination with low dose thalidomide (T) as salvage therapy for patients with relapsed or refractory multiple myeloma (MM) and Waldenstorm macroglobulinemia (WM) : Encouraging preliminary results[J]. Blood, 2004, 104(11): 2421.
-
10Richardson P G, Anderson K C. Multiple myeloma [ M]. London : Remedica Publishing, 2004 : 64.
共引文献31
-
1唐柳,陈晓敏,黄纯兰.多发性骨髓瘤患者化疗后发生医院感染的危险因素分析[J].解放军医学院学报,2019,40(12):1127-1132. 被引量:12
-
2丛琳,肖静,张文娟,李召,杨少婵,鲍雪临,赵春红.多发性骨髓瘤患者血清VEGF和TNF-α及IL-6表达与沙利度胺联合化疗相关性研究[J].中华肿瘤防治杂志,2012,19(5):375-377. 被引量:14
-
3闫顺朝,张凌云,曲秀娟,焦昕,侯柯佐,滕月娥,刘云鹏.PS341对他莫昔芬诱导乳腺癌MCF-7细胞凋亡影响及其机制的探讨[J].中华肿瘤防治杂志,2012,19(10):731-734.
-
4肖静,丛琳,张文娟,李召,杨少婵,鲍雪临,赵春红,厉吉霞,姜虹,贺长虹.多发性骨髓瘤治疗前后血清NTX-Ⅰ和BALP及OPG变化临床意义分析[J].中华肿瘤防治杂志,2012,19(14):1112-1114. 被引量:9
-
5周雅雯,左丽宏.雷利度胺在多发性骨髓瘤患者中的应用及效果观察[J].齐鲁护理杂志,2013,19(3):5-7.
-
6陈蓓莉,王晓桃,林文远,刘冯.抑制磷脂酰肌醇-3激酶信号通路对骨髓瘤细胞凋亡的实验研究[J].中外医学研究,2013,11(15):9-10.
-
7曹静,黄琨,徐敏.硼替佐米联合地塞米松治疗多发性骨髓瘤20例临床疗效分析[J].癌症进展,2013,11(6):551-553. 被引量:5
-
8蒋宜伟,刘宗权,宋敏,雷斌.淫羊藿不同提取物对去势大鼠PINP、NTx影响的实验研究[J].中国骨质疏松杂志,2014,20(2):142-144. 被引量:5
-
9刘宗权,宋敏,蒋宜伟,雷斌.淫羊藿苷抗骨质疏松对去势大鼠PINP,NTx影响的实验研究[J].甘肃中医学院学报,2014,31(3):4-7. 被引量:4
-
10张建华,董春霞,任方刚,覃艳红,杨林花.人破骨细胞的体外分离培养及与骨髓瘤细胞的相互作用[J].首都医科大学学报,2014,35(5):572-576. 被引量:2
同被引文献13
-
1邱录贵.多发性骨髓瘤的发病与国人特点[J].中国实用内科杂志:临床前沿版,2006,26(6):886-888. 被引量:52
-
2Hoffman R. Hematology-basic principles and practice[M].北京:科学出版社,1998:1403—1410.
-
3Anderson KC, Alsina M,Bensinger W,et al.NCCN clinnical prac- tice guideline in oncology multiple myeloma[J]. J Natl Compr Canc Netw,2013,11(1): 11-17.
-
4Jagannath S, Barlogie B, Berenson J ,et al.A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma[J]. Br J Haematol, 2004,127 (2) : 165-72.
-
5Fermand JP, Ravaud P, Chevret S,et al. High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma~ up-front or rescue treatment Results of a multicenter sequential randomized clinical trial[J]. Blood, 1998, 92 (9): 3131-3136.
-
6Morabito F, Gentile M, Mazzone C, et al. Safety and efficacy of bortezomib-melphalan-prednisone-thalidomide followed by borte zomib- thalidomide maintenance (VMPT-VT) versus bortezomib- melphalan-prednisone (VMP) [J]. Blood, 2011,118 (22) : 5759- 5766.
-
7钟玉萍,陈世伦,李新,胡影,张佳佳.硼替佐米为主的化疗方案治疗60例多发性骨髓瘤患者的临床分析[J].中国实验血液学杂志,2009,17(1):214-217. 被引量:24
-
8吴圣豪,郑翠苹,徐杰.硼替佐米对K562细胞株细胞增殖活性影响的初步研究[J].中国药物与临床,2012,12(6):735-736. 被引量:1
-
9康岩,赵月莹,郭梅,余长林,乔建辉,胡锴勋,孙琪云.减低剂量的硼替佐米治疗老年性多发性骨髓瘤临床研究[J].第二军医大学学报,2012,33(10):1142-1144. 被引量:7
-
10司丽.浅谈多发性骨髓瘤的发病机制及治疗进展[J].中国医药指南,2013,11(1):64-65. 被引量:2
二级引证文献4
-
1高红秀.硼替佐米联合环磷酰胺对多发性骨髓瘤患者免疫因子、免疫细胞水平的影响[J].中国合理用药探索,2019,0(12):117-120. 被引量:2
-
2司霞,宋荣景,陈月,冯婉玉.硼替佐米在不同剂量下治疗多发性骨髓瘤的Meta分析[J].中国临床药理学杂志,2016,32(7):660-662. 被引量:10
-
3戚永磊,赵莹,陈焯文.硼替佐米联合环磷酰胺治疗多发性骨髓瘤的应用与优越性分析[J].中国现代药物应用,2017,11(14):4-6. 被引量:4
-
4王军,肖湘,刘婷婷,唐银星,陈佳,宋森花,郑云艳,姜道滋.多发性骨髓瘤合并肾功能不全失代偿期的临床治疗[J].华南国防医学杂志,2015,29(6):439-441. 被引量:1
-
1雷军强,柴文晓.肝癌介入治疗现状[J].甘肃科学学报,2011,23(1):82-86. 被引量:21
-
2叶胜龙.重视原发性肝癌治疗的规范化[J].中华肝脏病杂志,2009,17(6):401-402. 被引量:7
-
3李维权,宋茂民.73例乳腺癌MRP、P53、ER、PR蛋白表达及临床意义[J].中国病案,2011,12(2):21-22. 被引量:3
-
4侯健,尚佩沛.多发性骨髓瘤的整体治疗策略[J].白血病.淋巴瘤,2010,19(7):385-387.
-
5刘佳,钟璐.男性原发性乳腺淋巴瘤一例并文献复习[J].白血病.淋巴瘤,2015,24(10):615-617. 被引量:1
-
6张英燕,曾建芳,罗秀玉.同步放化疗治疗晚期非小细胞肺癌的疗效观察[J].广州医药,2016,47(3):26-28. 被引量:7
-
7刘勤科.骨转移瘤的CT和X线诊断[J].内蒙古中医药,2012,31(6):86-87. 被引量:4
-
8李训海,殷德涛.甲状腺癌86例临床诊治分析[J].中国实用医刊,2014,41(8):20-21. 被引量:6
-
9高云,刘广舒.乳腺癌新辅助化疗研究进展[J].医学理论与实践,2013,26(24):3250-3252. 被引量:7
-
10牟鹏,厉红元.乳腺癌新辅助化疗的研究进展[J].中国普外基础与临床杂志,2011,18(9):1011-1016. 被引量:48