他汀类药物与新发糖尿病风险:他汀类药物的整体获益仍然明显超过潜在风险
Statins and the risk of developing diabetes:Overall benefits of statins still clearly outweigh potential risks
摘要
他汀类药物是治疗脂代谢紊乱的重要基础,然而最近一项随机对照试验的荟萃(Meta)分析结果显示他汀类药物的应用与新发糖尿病相关1。Carter等的一项相关的观察研究发现(doi:10.1136/bmj.12610,见本后文相关链接)为这一观点提供了有力证据2。他们采用流行病学的方法,对加拿大安大略省的行政管理数据库中年龄大于66岁的他汀类药物使用者,进行了回顾性分析,比较不同他汀类药物引起新发糖尿病的相对风险。
出处
《英国医学杂志中文版》
2013年第5期267-268,共2页
The BMJ Chinese Edition
参考文献9
-
1Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJM, et al. Statins and risk of incident diabetes: a collaborati ve meta-analysis of randomised statin trials. Lancet 2010 ;375: 735-42.
-
2Carter AA, Gomes T, Camacho X, Juurlink DN, Shah BR, Mamadani MM. Risk of incident diabetes among patients treated with statins , population based study. BMJ 2013 ; 346 : 12610.
-
3Preiss D, Seshasai SRK, Welsh P, Murphy SA, Ho JE , Waters DD, et al. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy. JAMA 2011 ;305 :2556-64.
-
4Cholesterol Treatment Trialists (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet 2010 ;376: 1670-81.
-
5Task Force for the Management of Dyslipidemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society. ESC/EAS guidelines for the management of dyslipidemias. Eur Heart J 2011 ;32: 1769-818.
-
6Iula A, Mamiemi J, Huupponen R, Virtanen A, Rastas M, Honnemaa T. Effects of dietand simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men. A randomized controlled trial. JAMA 2002;287 :598-605.
-
7Cholesterol Treatment Trialists (CTT) Collaborators. Efficacy of cholesterol-loweringtherapy in 18 686 people with diabetes in 14 randomised trials of statins , a meta-analysis. Lancet 2008; 371 : 117- 25.
-
8Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol2005 ;45 :89-118.
-
9Sattar N, Taskinen MR. Statins are diabetogenic-myth or reality? Atherosclerosis Suppl 2012 ; 13 : 1-10.
-
1江涛.Irbesartan可有效治疗肥胖高血压患者[J].国外医学情报,2006,27(6):38-39.
-
2申露(摘译).阿司匹林对感染性心内膜炎无效[J].中华医学信息导报,2008,23(4):11-11.
-
3米氮平可提高抑郁症患者的驾驶安全性[J].中华医学信息导报,2009,24(12):14-14.
-
4何瑞豪.阿托伐他汀与氨氯地平联合治疗原发性高血脂的临床研究[J].中国医药指南,2014,12(25):120-121. 被引量:1
-
5国外[J].糖尿病之友,2015,0(8):11-11.
-
6孙嘉临,王先化.秋水仙碱对实验性大鼠肝纤维化的影响[J].中国现代医生,2012,50(14):1-2. 被引量:14
-
7张伟(摘译),吴佳(校译).对比评价西酞普兰在妇女妊娠期对孕妇和胎儿的影响[J].中国药师,2007,10(6):601-601.
-
8徐进,李平,周彤,张浩,桂小臣,蒋文臣.不同剂量舒芬太尼抑制依托咪酯引起肌震颤反应的比较[J].中国临床药理学杂志,2013,29(10):789-791. 被引量:6
-
9Jacobs E,Schwarzschild M.A,A. Ascherio,邱伟庆.非甾体抗炎药的使用与帕金森病风险的关系[J].世界核心医学期刊文摘(神经病学分册),2006,2(5):16-16. 被引量:1
-
10孙薇(译).长期服用阿司匹林能预防癌症吗?——可能有效,但回答此问题需特别设计的临床试验[J].英国医学杂志中文版,2011,14(3):138-140.