结直肠癌术后肠梗阻相关因素分析

Analysis of Factors Associated with Postoperative Ileus after Colorectal Cancer Surgery

背景：结直肠癌术后肠梗阻（POI）并不罕见，其影响患者术后营养状况，减缓预后。目前关于POI危险因素的研究甚少。目的：分析结直肠癌术后发生POI的危险因素。方法：纳入2009年1月～2013年3月于扬州市第一人民医院行结直肠癌手术的患者，采集18项POI可疑危险因素，筛选POI发生相关因素，行多元逐步logistic回归模型分析。结果：共187例患者纳入研究，31例（16．6％）发生POI，性别、吸烟史、慢性阻塞性肺病（COPD）史、白蛋白水平、直肠肿瘤、回肠造瘘与POI的发生相关（P〈0．05）。多元逐步logistic回归模型分析结果显示性别、COPD史、回肠造瘘是POI发生的独立危险因素（P〈0．05）。结论：性别、COPD史、回肠造瘘是结直肠癌POI的重要因素。

Background： Postoperative ileus （POI） after colorectal cancer surgery is not rare, it can influence postoperative nutritional status and slow patient＇ s recovery. So far, information about the factors associated with POI after colorectal cancer surgery was limited. Aims： To analyze the factors associated with POI after colorectal cancer surgery. Methods： Patients with colorectal cancer from January 2009 to March 2013 at Yangzhou First People＇ s Hospital were enrolled in this study. Eighteen suspected factors were analyzed for identifying POI related factors, then multivariate logistic regression model was conducted to analyze the risk factors. Results： A total of 187 eligible patients were selected in this investigation, 31 cases （16.6%） had POI occurred. Sex, smoking, chronic obstructive pulmonary disease （COPD）, level of albumin, rectal tumor as well as ileal fistula were correlated with POI （ P 〈 0.05 ）. Sex, COPD and ileal fistula were identified as the independent POI risk factors （ P 〈 0.05 ）. Conclusions： Sex, COPD and ileal fistula are important risk factors for POI after colorectal cancer surgery.