缺氧诱导因子-2α对脂代谢的调节作用

Regulatory Effect of Hypoxia-inducible Factor-2α on Lipid Metabolism

缺氧诱导因子-2α(HIF-2α)是一种在缺氧条件下广泛存在于哺乳动物和人体内的氧敏感性转录因子,通过调节缺氧诱导基因表达参与组织细胞对低氧的适应性应答,其表达是机体适应低氧的关键环节和起始步骤。近年研究发现HIF-2α可能与脂代谢过程有密切联系。本文就HIF-2α对脂肪酸代谢和胆固醇代谢的调节作用作一综述。

Hypoxia-inducible factor-2α （HIF-2α） is an oxygen-sensitive transcription factor that widely exists in mammals and humans under hypoxia. It participates in tissue adaptive response to hypoxia via regulating hypoxia-induced genes expression. Expression of HIF-2α is considered as a critical and initial step in hypoxic adaption. Recent studies suggested that HIF-2ct might be closely associated with lipid metabolism. This article reviewed the regulatory effect of HIF- 2α on fatty acids and cholesterol metabolism.