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FTY720抗肿瘤作用及其机制的研究进展 被引量：1

Advances in Study on Anti-cancer Effect and Mechanism of FTY720
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摘要 FTY720是一种由冬虫夏草培养液多球壳菌素合成的鞘氨醇类似物,作为一种新型的免疫抑制剂广泛应用于临床复发型多发性硬化症的治疗。近年研究发现FTY720还能诱导多种肿瘤细胞凋亡、增强化疗敏感性、抑制肿瘤转移。本文就FTY720抗肿瘤作用及其机制的研究进展作一综述。 FTY720, a synthetic sphingosine analogue of myriocin derived from culture filtrates of Isaria sinclairii, has been widely used in the treatment of relapsing forms of multiple sclerosis as a novel immunosuppressant. Recent studies indicate that FTY720 can induce apoptosis, enhance chemotherapy effect, as well as inhibit metastasis in several cancers. This article reviewed the advances in study on the anti-cancer effect and mechanism of FTY720.
作者 邢颖 王志红 韩英
机构地区 浙江省湖州市中国人民解放军第 北京军区总医院消化内科
出处 《胃肠病学》 2013年第10期633-635,共3页 Chinese Journal of Gastroenterology
关键词 FTY720 肿瘤 细胞凋亡 抗药性 肿瘤 肿瘤转移 FTY720 Neoplasms Apoptosis Drug Resistance, Neoplasm Neoplasm Metastasis
分类号 R965 [医药卫生—药理学]
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参考文献25

  • 1Brinkmann V,Davis MD,Heise CE,et al.The immune modulator FTY720 targets sphingosine 1-phosphate receptors[J].J Biol Chem,2002,277 (24):21453-21457.
  • 2Saida T,Kikuchi S,Itoyama Y,et al.A randomized,controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis[J].Mult Scler,2012,18 (9):1269-1277.
  • 3Lim KG,Tonelli F,Li Z,et al.FTY720 analogues as sphingosine kinase 1 inhibitors:enzyme inhibition kinetics,allosterism,proteasomal degradation,and actin rearrangement in MCF-7 breast cancer cells[J].J Biol Chem,2011,286 (21):18633-18640.
  • 4Zhang N,Qi Y,Wadham C,et al.FTY720 induces necrotic cell death and autophagy in ovarian cancer cells:a protective role of autophagy[J].Autophagy,2010,6 (8):1157-1167.
  • 5Pchejetski D,Bohler T,Brizuela L,et al.FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1[J].Cancer Res,2010,70 (21):8651-8661.
  • 6Liao A,Hu R,Zhao Q,et al.Autophagy induced by FTY720 promotes apoptosis in U266 cells[J].Eur J Pharm Sci,2012,45 (5):600-605.
  • 7Alinari L,Baiocchi RA,Praetorius-Ibba M.FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma:is FTY720 the next autophagy-blocking agent in lymphoma treatment[J] ? Autophagy,2012,8 (3):416-417.
  • 8Li CX,Shao Y,Ng KT,et al.FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells[J].PLoS One,2012,7 (2):e32380.
  • 9Zheng T,Meng X,Wang J,et al.PTEN-and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice[J].J Cell Biochem,2010,111 (1):218-228.
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二级参考文献10

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  • 9Azuma H,Takahara S,Horie S,et al.Induction of apoptosis in hu-man bladder cancer cellsin vitroandin vivocaused by FTY720treatment[].Journal d Urologie.2003
  • 10Sonoda Y,Yamamoto D,Sakurai S,et al.FTY720,a novel immunosuppressive agent,induces apoptosis in human glioma cells[].Biochemical and Biophysical Research Communications.2001

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胃肠病学
2013年 第10期

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