胃食管反流病相关的细胞间隙增宽和紧密连接蛋白

Gastroesophageal Reflux Disease Related Dilated Intercellular Spaces and Tight Junction Proteins

食管黏膜防御能力下降在胃食管反流病(GERD)的发生中起重要作用。食管黏膜防御功能主要由上皮屏障完成,包括上皮细胞膜和紧密连接(TJ)。研究发现,GERD患者食管上皮层TJ蛋白表达和分布异常可能导致上皮细胞间隙增宽(DIS),这也许能作为GERD食管形态结构异常的客观指标。因此,探讨TJ蛋白、DIS与GERD之间的联系具有重要临床意义,可为GERD的诊断、治疗甚至疗效评估提供新的方向。

Lowering of defense capability of esophageal mucosa plays an important role in the pathogenesis of gastroesophageal reflux disease （GERD）. The defense function of esophageal mucosa is mainly completed by epithelial barrier, including epithelial cell membrane and tight junction （TJ）. Studies have found that abnormal expression and distribution of esophageal epithelium TJ proteins may cause dilated intercellular spaces （DIS） in GERD patients. DIS may be served as an objective indicator of abnormal morphological structure of GERD esophagus. Therefore, investigating the correlation between TJ proteins, DIS and GERD has important clinical significance. It may provide a new direction for diagnosis and treatment of GERD, even for evaluation of therapeutic effect.