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Circulating ghrelin was negatively correlated with pulmonary arterial pressure in atrial septal defect patients

Circulating ghrelin was negatively correlated with pulmonary arterial pressure in atrial septal defect patients
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摘要 Background Ghrelin was found to attenuate the magnitude of pulmonary arterial hypertension and pulmonary vascular remodeling in rats. The objective of this study was to explore the fasting plasma ghrelin level and the relationships between ghrelin and pulmonary arterial pressure (PAP) in atrial septal defect (ASD) patients with pulmonary arterial hypertension (PAH), Background Ghrelin was found to attenuate the magnitude of pulmonary arterial hypertension and pulmonary vascular remodeling in rats. The objective of this study was to explore the fasting plasma ghrelin level and the relationships between ghrelin and pulmonary arterial pressure (PAP) in atrial septal defect (ASD) patients with pulmonary arterial hypertension (PAH),
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第20期3936-3939,共4页 中华医学杂志(英文版)
关键词 GHRELIN OBESTATIN atrial septal defect pulmonary arterial hypertension ghrelin obestatin atrial septal defect," pulmonary arterial hypertension
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参考文献17

  • 1Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptides from stomach. Nature 1999; 402: 656-660.
  • 2Soares JB, Leite-Moreira AF. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 2008; 29: 1255-1270.
  • 3Kishimoto 1, Tokudome T, Hosoda H, Miyazato M, Kangawa K. Ghrelin and cardiovascular diseases. J Cardiol 2012; 59: 8-13.
  • 4Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, et al. Hemodynamic and hormonal effects of human ghrelin in healthy voluntees. Am J Physiol Regul Integr Comp Physiol 2001; 280: R1483-R1487.
  • 5Matsumura K, Tsuchihashi T, Fujii K, Abe I, lida M. Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension 2002; 40: 694-699.
  • 6Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I, et al. Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. Endocrinology 2008; 149:237-244.
  • 7Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996- 999.
  • 8Anderwald-Stadler M, Krebs M, Promintzer M, Mandl M, Bischof MG, Nowotny P, et al. Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans. Am J Physiol Endocrinol Metab 2007; 293:E1393-E1398.
  • 9Li ZF, Guo ZF, Cao J, Hu JQ, Zhao XX, Xu RL, et al. Plasma ghrelin and obestatin levels are increased in spontaneously hypertensive rats. Peptides 2010; 31 : 297-300.
  • 10Li ZF, Guo ZF, Yang SG, Zheng X, Cao J, Qin YW. Circulating ghrelin and ghrelin to obestatin ratio are low in patients with untreated mild-to-moderate hypertension. Regul Pept 2010; 165: 206-209.

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