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mTOR信号通路在CD4^+T细胞分化中的作用 被引量：6

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摘要 哺乳动物雷帕霉素靶蛋白(mTOR)是进化保守的PI3K激酶家族成员之一,在整合环境信号如氨基酸,能量和生长因子等方面具有重要的作用。T细胞分化与细胞代谢的调节有着紧密的联系,T细胞依靠mTOR信号整合免疫信号和代谢信号来维持合适的稳定和激活。CD4+T细胞在适应性免疫应答和免疫调节中发挥着重要作用。近年研究发现,mTOR信号与CD4+T细胞亚群分化有很大的关系。本文对mTOR信号调节CD4+T细胞分化的研究进展进行综述。
作者 伍宁波 苏冰
机构地区 上海交通大学医学院上海市免疫学研究所
出处 《现代免疫学》 CAS CSCD 北大核心 2013年第6期500-504,共5页 Current Immunology
基金 上海市科委基金资助项目(13JC1404700 12ZR1448600) 上海市卫生局基金资助项目(20124196)
关键词 MTOR CD4+T细胞分化 辅助性T细胞 调节性T细胞
分类号 R392 [医药卫生—免疫学]
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参考文献24

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同被引文献49

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引证文献6

二级引证文献10

现代免疫学
2013年 第6期

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