窒息新生儿血清超氧化物歧化酶的变化与脑损伤程度的关系

The Changes of Superoxide Dismutase (SOD) in the Serum of Asphyxiated Newborns and Its Relation to Severity of Brain Damage

为探讨血清超氧化物歧化酶在窒息后新生儿脑损伤中的作用 ,采用放射免疫法 (双抗体法 )对 38例窒息新生儿血清SOD活性测定 ,并以正常足月儿 30例作对照组。结果①窒息新生儿血清SOD活性较对照组低 ,差异显著(P <0 0 1) ;②重度窒息儿血清SOD活性较轻度窒息儿低 ,差异显著 (P <0 0 1) ;③合并HIE的窒息儿血清SOD活性较无HIE的窒息儿低 ,差异显著 (P <0 0 1)。结果表明血清SOD活性与窒息及脑损伤程度一致。

To study the role of SOD in the serum in asphyxiated newborns with brain damage, ith 30 normal full term infants as control, 38 asphyxiated newborns were enrolled for study. The SOD activity was measured by a sensitive radioimmunoassay(bi-antiamboceptor).Results:①Compared with the control group, the SOD activity in serum of asphyxiated group was decreased. With significant differences (P<0.01).②The SOD activity in serum of the severe asphyxiated group was significantly lower than that of mild group (P<0.01).③SOD in serum of asphyxiated newborns with complicated HIE was lower than those without HIE and there were significant difference (P<0.01).The results suggest that the SOD activity in serum accords with the severity of asphyxia and brain damage.