温阳利水治则改善(脾肾阳虚型)2型糖尿病代谢紊乱的临床研究

Clinical reserch of the therapeutic principle of warming yang and promote diuresis of improving the disorders of metabolism of T2DM

目的通过对比温阳利水治则与吡格列酮的临床疗效,讨论温阳利水治则改善2型糖尿病代谢紊乱的可能机制。方法将120例受试者按随机编号顺序分入治疗组或对照组,进入12周的试验期。于治疗12周以后检测空腹静脉血浆葡萄糖(FPG)、糖化血红蛋白(HbA1C)、体重指数(BMI)、总胆固醇(TC),进行疗效观察。采用SPSS13.0统计分析软件进行计算分析。两组指标比较采用t检验。结果与对照组比较,BMI、FPG、TC水平均优于对照组(P<0.05)。试验组、对照组的HbA1C组间差异无统计学意义(P>0.05)。结论温阳利水治则联合吡格列酮较单用吡格列酮更有效改善2型糖尿病糖代谢紊乱,同时温阳利水治则能更大程度改善腹型肥胖,减低体重,具有其独特的优势。

Objective To discuss the mechanism of the therapeutic principle of warming yang and promote diuresis of improving the disorders of metabolism of T2DM, through the comparison of therapeutic effect of the therapeutic principle of warming yang and promote diuresis with pioglitazone. Methods 120 subjects were divided into test group or control group randomly. We observed the therapeutic effect after 12 weeks＇ trails, and measured the level of FPG, HbA1C, BMI , TC,after 12 weeks＇ treatment, analyzed the data through the SPSS 13.0, and analyzed the data of test group and control group with t-test. Results Compared with the control group, the BMI and the level of FPG,TC of test group had been improved （P 〈 0.05）. There was no significant difference of HbA1C between the control group and the test group（P 〉 0.05）. Conclusion Combining the therapeutic principle of warming yang and promote diuresis with pioglitazone is better than using pioglitazone singlely in improving the disorders of sugar and lipid of T2DM. And the therapeutic principle of warming yang and promote dieresis can better improve the abdominal obesity and lower the body weight.